Curated Information
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Curated Information Page
PubMed Id: 20023648 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Bekker-Jensen S, et al. (2010) HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes. Nat Cell Biol 12, 80-6; sup pp 1-12 20023648
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T4827-p - HERC2 (human)
Orthologous residues
HERC2 (human): T4827‑p, HERC2 (mouse): T4829‑p, HERC2 iso2 (mouse): T4793‑p, HERC2 (rat): T4772‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Disease tissue studied:  bone cancer
 Relevant cell lines - cell types - tissues:  293T (epithelial), U2OS (bone cell)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
caffeine decrease
NU7441 decrease
Downstream Regulation
 Effect of modification (function):  molecular association, regulation, ubiquitination
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
RNF8 (human) FHA Induces ubiquitination, molecular association, regulation co-immunoprecipitation
 Comments:  stabilizes an interaction of RNF8 with MDC1 or Ubc13


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