Curated Information
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Curated Information Page
PubMed Id: 19966802 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Wang H, et al. (2010) Skp2 is required for survival of aberrantly proliferating Rb1-deficient cells and for tumorigenesis in Rb1+/- mice. Nat Genet 42, 83-8 19966802
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T187-p - p27Kip1 (mouse)
Orthologous residues
p27Kip1 (human): T187‑p, p27Kip1 (mouse): T187‑p, p27Kip1 (rat): T187‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Disease tissue studied:  eye cancer, retinoblastoma
 Relevant cell lines - cell types - tissues:  pituitary gland [genetic knockin], RB177 (retinal), Y79 (retinal)
 Cellular systems studied:  cell lines, tissue
 Species studied:  human, mouse
Downstream Regulation
 Effect of modification (function):  ubiquitination
 Effect of modification (process):  apoptosis, altered


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