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Orthologous residues
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p27Kip1 (human): T187‑p, p27Kip1 (mouse): T187‑p, p27Kip1 (rat): T187‑p
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Characterization
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Methods used to characterize site in vivo:
mutation of modification site
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Disease tissue studied:
eye cancer, retinoblastoma
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Relevant cell lines - cell types - tissues:
pituitary gland [genetic knockin], RB177 (retinal), Y79 (retinal)
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Cellular systems studied:
cell lines, tissue
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Species studied:
human, mouse
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Downstream Regulation
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Effect of modification (function):
ubiquitination
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Effect of modification (process):
apoptosis, altered
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