Curated Information
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Curated Information Page
PubMed Id: 19901077 
Lim KH, et al. (2010) Aurora-A phosphorylates, activates, and relocalizes the small GTPase RalA. Mol Cell Biol 30, 508-23 19901077
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Download Sites

S194-p - RALA (human)
Orthologous residues
RALA (human): S194‑p, RALA (mouse): S194‑p, RALA (rat): S194‑p
 Methods used to characterize site in vivo immunoprecipitation, microscopy-colocalization with upstream kinase, mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  293T (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE AurA (human) siRNA inhibition of enzyme, transfection of dominant-negative enzyme, transfection of constitutively active enzyme, transfection of wild-type enzyme, mutation in upstream enzyme recognition motif
Downstream Regulation
 Effect of modification (function):  intracellular localization, molecular association, regulation
 Effect of modification (process):  cell growth, altered, cytoskeletal reorganization
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
RALBP1 (human) Not reported activity, induced cytoskeletal reorganization co-immunoprecipitation
 Comments:  localization to plasma membrane
Associated Diseases
Diseases: Alterations: Comments:
pancreatic cancer

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.