Curated Information
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Curated Information Page
PubMed Id: 19893624 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Nakhaei P, et al. (2009) The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS signaling pathway by targeting TRAF3 for degradation. PLoS Pathog 5, e1000650 19893624
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S396-p - IRF3 (human)
Orthologous residues
IRF3 (human): S396‑p, IRF3 (mouse): S388‑p, IRF3 (rat): S390‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
DDX58 (human) increase
TRIAD3 (human) DDX58 (human) inhibit treatment-induced increase
MAVS (human) increase
TRIAD3 (human) MAVS (human) inhibit treatment-induced increase
TBK1 (human) increase
TRIAD3 (human) TBK1 (human) no effect upon treatment-induced increase

S477-p - IRF7 (human)
Orthologous residues
IRF7 (human): S477‑p, IRF7 (mouse): S431‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
DDX58 (human) no change compared to control
TRIAD3 (human) DDX58 (human) no change compared to control
MAVS (human) no change compared to control
TRIAD3 (human) MAVS (human) no change compared to control
TBK1 (human) increase
TRIAD3 (human) TBK1 (human) no effect upon treatment-induced increase

S479-p - IRF7 (human)
Orthologous residues
IRF7 (human): S479‑p, IRF7 (mouse): G433‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
DDX58 (human) no change compared to control
TRIAD3 (human) DDX58 (human) no change compared to control
MAVS (human) no change compared to control
TRIAD3 (human) MAVS (human) no change compared to control
TBK1 (human) increase
TRIAD3 (human) TBK1 (human) no effect upon treatment-induced increase


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