Curated Information
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Curated Information Page
PubMed Id: 19889641 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Mbefo MK, et al. (2010) Phosphorylation of synucleins by members of the Polo-like kinase family. J Biol Chem 285, 2807-22 19889641
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S129-p - SNCA (human)
Orthologous residues
SNCA (human): S129‑p, SNCA (mouse): S129‑p, SNCA (rat): S129‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry (in vitro), phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'brain, hippocampus', 293 (epithelial), HeLa (cervical), neuron-'brain, hippocampus'
 Cellular systems studied:  cell lines
 Species studied:  human, mouse, rat
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE PLK2 (human)
KINASE PLK3 (human)
KINASE PLK1 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PLK3 (human) siRNA inhibition of enzyme, phospho-antibody, transfection of wild-type enzyme, microscopy-colocalization
KINASE PLK2 (human) siRNA inhibition of enzyme, phospho-antibody, transfection of wild-type enzyme, microscopy-colocalization
Associated Diseases
Diseases: Alterations: Comments:
Alzheimer's disease increased Lewybody disease

S118-p - SNCB (human)
Orthologous residues
SNCB (human): S118‑p, SNCB (mouse): S117‑p, SNCB (rat): S118‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry (in vitro), phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'brain, hippocampus', 293 (epithelial), HeLa (cervical), neuron-'brain, hippocampus'
 Cellular systems studied:  cell lines
 Species studied:  human, mouse, rat
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE PLK1 (human)
KINASE PLK3 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PLK3 (human) phospho-antibody, transfection of wild-type enzyme
KINASE PLK1 (human) phospho-antibody
KINASE PLK2 (human) phospho-antibody, transfection of wild-type enzyme


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