Curated Information
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Curated Information Page
PubMed Id: 17545617 
LeRoy PJ, et al. (2007) Localization of human TACC3 to mitotic spindles is mediated by phosphorylation on Ser558 by Aurora A: a novel pharmacodynamic method for measuring Aurora A activity. Cancer Res 67, 5362-70 17545617
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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T288-p - AurA (human)
Orthologous residues
AurA (human): T288‑p, AurA (mouse): T279‑p, AurA (rat): T281‑p, AurA (pig): T288‑p, AurA (frog): T295‑p
 Methods used to characterize site in vivo phospho-antibody
 Relevant cell lines - cell types - tissues:  HCT116 (intestinal)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
MLN8054 decrease
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced

S558-p - TACC3 (human)
Orthologous residues
TACC3 (human): S558‑p, TACC3 (mouse): S347‑p, TACC3 (pig): S460‑p, TACC3 (chicken): S574‑p
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  HCT116 (intestinal)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE AurA (human)
Downstream Regulation
 Effect of modification (function):  intracellular localization
 Comments:  changed localization in the presence of MLN8054

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