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Orthologous residues
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|
Notch 1 (human): T2511‑p, Notch 1 (mouse): T2487‑p
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|
Characterization
|
|
Methods used to characterize site in vivo:
mutation of modification site
|
|
Relevant cell lines - cell types - tissues:
293 (epithelial)
|
|
Cellular systems studied:
cell lines
|
|
Species studied:
human
|
|
Downstream Regulation
|
|
Effect of modification (function):
molecular association, regulation, protein degradation, ubiquitination
|
|
Modification regulates interactions with:
|
|
Interacting molecule
|
Interacting domains
|
Effect
|
Consequences (function)
|
Consequences (process)
|
Detection assays
|
|
FBXW7 (human)
|
|
Induces
|
|
|
co-immunoprecipitation
|
|
