Curated Information
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PubMed Id: 17510392 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Vikis H, et al. (2007) EGFR-T790M is a rare lung cancer susceptibility allele with enhanced kinase activity. Cancer Res 67, 4665-70 17510392
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S473-p - Akt1 (human)
Orthologous residues
Akt1 (human): S473‑p, Akt1 (mouse): S473‑p, Akt1 (rat): S473‑p, Akt1 (fruit fly): S586‑p, Akt1 (cow): S473‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  293T (epithelial), A293T ('renal, embryonic'), COS (fibroblast), HBEC3 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human, monkey

Y1016-p - EGFR (human)
Orthologous residues
EGFR (human): Y1016‑p, EGFR iso5 (human): Y1016‑p, EGFR (mouse): Y1018‑p, EGFR (rat): Y1017‑p, EGFR (pig): Y1016‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  293T (epithelial), A293T ('renal, embryonic'), COS (fibroblast), HBEC3 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human, monkey

Y1092-p - EGFR (human)
Orthologous residues
EGFR (human): Y1092‑p, EGFR iso5 (human): , EGFR (mouse): Y1092‑p, EGFR (rat): Y1091‑p, EGFR (pig): Y1091‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  293T (epithelial), A293T ('renal, embryonic'), COS (fibroblast), HBEC3 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human, monkey
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
gefitinib EGFR (human) decrease Iressa does not inhibit phosphorylation of T790M mutant

T202-p - ERK1 (human)
Orthologous residues
ERK1 (human): T202‑p, ERK1 (mouse): T203‑p, ERK1 (rat): T203‑p, ERK1 (hamster): T192‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  293T (epithelial), A293T ('renal, embryonic'), COS (fibroblast), HBEC3 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human, monkey

Y204-p - ERK1 (human)
Orthologous residues
ERK1 (human): Y204‑p, ERK1 (mouse): Y205‑p, ERK1 (rat): Y205‑p, ERK1 (hamster): Y194‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  293T (epithelial), A293T ('renal, embryonic'), COS (fibroblast), HBEC3 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human, monkey

T185-p - ERK2 (human)
Orthologous residues
ERK2 (human): T185‑p, ERK2 (mouse): T183‑p, ERK2 (rat): T183‑p, ERK2 (chicken): T193‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  293T (epithelial), A293T ('renal, embryonic'), COS (fibroblast), HBEC3 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human, monkey

Y187-p - ERK2 (human)
Orthologous residues
ERK2 (human): Y187‑p, ERK2 (mouse): Y185‑p, ERK2 (rat): Y185‑p, ERK2 (chicken): Y195‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  293T (epithelial), A293T ('renal, embryonic'), COS (fibroblast), HBEC3 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human, monkey


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