Curated Information
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Curated Information Page
PubMed Id: 11158290 
Heissmeyer V, Krappmann D, Hatada EN, Scheidereit C (2001) Shared pathways of IkappaB kinase-induced SCF(betaTrCP)-mediated ubiquitination and degradation for the NF-kappaB precursor p105 and IkappaBalpha. Mol Cell Biol 21, 1024-35 11158290
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S923-p - NFkB-p105 (human)
Orthologous residues
NFkB‑p105 (human): S923‑p, NFkB‑p105 (mouse): S926‑p, NFkB‑p105 (rat): S927‑p
Characterization
 Methods used to characterize site in vivo electrophoretic mobility shift, immunoprecipitation, western blotting
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE IKKB (human)

S927-p - NFkB-p105 (human)
Orthologous residues
NFkB‑p105 (human): S927‑p, NFkB‑p105 (mouse): S930‑p, NFkB‑p105 (rat): S931‑p
Characterization
 Methods used to characterize site in vivo electrophoretic mobility shift, immunoprecipitation
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE IKKB (human)
Downstream Regulation
 Effect of modification (function):  protein degradation


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