Curated Information
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Curated Information Page
PubMed Id: 17535800 
Lyons TR, et al. (2007) Regulation of the Pro-apoptotic scaffolding protein POSH by Akt. J Biol Chem 282, 21987-97 17535800
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
Download Sites

S304-p - SH3RF1 (human)
Orthologous residues
SH3RF1 (human): S304‑p, SH3RF1 (mouse): S304‑p, SH3RF1 iso2 (mouse): S274‑p, SH3RF1 (rat): S305‑p
 Methods used to characterize site in vivo mass spectrometry (in vitro), mutation of modification site
 Disease tissue studied:  breast cancer
 Relevant cell lines - cell types - tissues:  MDA-MB231 (breast cell)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Akt2 (human)
KINASE Akt1 (human)
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  apoptosis, inhibited
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
RAC1 (human) Induces molecular association, regulation apoptosis, inhibited co-immunoprecipitation

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.