Curated Information
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Curated Information Page
PubMed Id: 17535800 
Lyons TR, et al. (2007) Regulation of the Pro-apoptotic scaffolding protein POSH by Akt. J Biol Chem 282, 21987-97 17535800
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
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S304-p - SH3RF1 (human)
Orthologous residues
SH3RF1 (human): S304‑p, SH3RF1 (mouse): S304‑p, SH3RF1 iso2 (mouse): S274‑p, SH3RF1 (rat): S305‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry (in vitro), mutation of modification site
 Disease tissue studied:  breast cancer
 Relevant cell lines - cell types - tissues:  MDA-MB231 (breast cell)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Akt1 (human)
KINASE Akt2 (human)
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  apoptosis, inhibited
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
RAC1 (human) Induces molecular association, regulation apoptosis, inhibited co-immunoprecipitation


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