Curated Information

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Curated Information Page

PubMed Id: 17525164

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Information from this record has been curated, but not yet edited in PhosphoSitePlus^® and may be incomplete.

Um JH, et al. (2007) Activation of 5'-AMP-activated kinase with diabetes drug metformin induces casein kinase Iepsilon (CKIepsilon)-dependent degradation of clock protein mPer2. J Biol Chem 282, 20794-8 17525164

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

S389-p - CK1-E (human)

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Orthologous residues

CK1‑E (human): S389‑p, CK1‑E (mouse): S389‑p, CK1‑E (rat): S389‑p

Characterization

Methods used to characterize site in vivo: mutation of modification site, phospho-antibody, western blotting

Relevant cell lines - cell types - tissues: 3T3 (fibroblast)

Cellular systems studied: cell lines

Species studied: mouse

Enzymes shown to modify site in vitro:

Type	Enzyme
KINASE	AMPKA1 (human)

Upstream Regulation

Potential in vivo enzymes for site:

Type	Enzyme	Evidence	Notes
KINASE	AMPKA1 (mouse)	modification site within consensus motif

Downstream Regulation

Effect of modification (function): protein degradation

Effect of modification (process): transcription, altered

Comments: phaosphorylation induces degredation of mPer2 and expression of circadian clock genes.

T183-p - AMPKA1 (mouse)

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