Curated Information
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Curated Information Page
PubMed Id: 17482545 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Whalen EJ, et al. (2007) Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2. Cell 129, 511-22 17482545
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y326-p - ADRB2 (mouse) ▲
Orthologous residues
ADRB2 (human): Y326‑p, ADRB2 (mouse): Y326‑p, ADRB2 (rat): Y326‑p, ADRB2 (hamster): Y326‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human

S355-p - ADRB2 (mouse) ▲
Orthologous residues
ADRB2 (human): S355‑p, ADRB2 (mouse): S355‑p, ADRB2 (rat): S355‑p, ADRB2 (hamster): S355‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
epinephrine increase
epinephrine no change compared to control Y326A mutant ADRB2
GRK2 (cow) increase Y326A mutant ADRB2
CysNO GRK2 (cow) inhibit treatment-induced increase wild-type and C340S mutant GRK2
CysNO GRK2 (cow) no change compared to control C439S mutant GRK2

S356-p - ADRB2 (mouse) ▲
Orthologous residues
ADRB2 (human): S356‑p, ADRB2 (mouse): S356‑p, ADRB2 (rat): S356‑p, ADRB2 (hamster): S356‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
epinephrine increase
epinephrine no change compared to control Y326A mutant ADRB2
GRK2 (cow) increase Y326A mutant ADRB2
CysNO GRK2 (cow) inhibit treatment-induced increase wild-type and C340S mutant GRK2
CysNO GRK2 (cow) no change compared to control C439S mutant GRK2


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