Curated Information
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Curated Information Page
PubMed Id: 17993462 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Kim H, et al. (2008) Delta-catenin-induced dendritic morphogenesis. An essential role of p190RhoGEF interaction through Akt1-mediated phosphorylation. J Biol Chem 283, 977-87 17993462
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T454-p - CTNND2 (mouse)
Orthologous residues
CTNND2 (human): T457‑p, CTNND2 (mouse): T454‑p, CTNND2 (rat): T440‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site
 Relevant cell lines - cell types - tissues:  'neuron, hippocampal'-brain, 3T3 (fibroblast), MEF (fibroblast)
 Cellular systems studied:  cell lines, primary cultured cells
 Species studied:  mouse
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Akt1 (human)
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  cytoskeletal reorganization
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
RGNEF (mouse) Induces enzymatic activity, inhibited, molecular association, regulation cytoskeletal reorganization co-immunoprecipitation
 Comments:  regulates dendrite formation in hippocampal neurons; interaction with CTNND2 prevents RGNEF from interacting with and activating RhoA.


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