Curated Information

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Curated Information Page

PubMed Id: 17988215

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Vergarajauregui S, Oberdick R, Kiselyov K, Puertollano R (2008) Mucolipin 1 channel activity is regulated by protein kinase A-mediated phosphorylation. Biochem J 410, 417-25 17988215

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

S557-p - mucolipin 1 (human)

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Orthologous residues

mucolipin 1 (human): S557‑p, mucolipin 1 (mouse): S557‑p, mucolipin 1 (rat): S557‑p

Characterization

Methods used to characterize site in vivo: [32P] bio-synthetic labeling, immunoprecipitation, mutation of modification site, western blotting

Relevant cell lines - cell types - tissues: 293 (epithelial), HeLa (cervical)

Cellular systems studied: cell lines

Species studied: human

Enzymes shown to modify site in vitro:

Type	Enzyme
KINASE	PKACa (human)

Upstream Regulation

Potential in vivo enzymes for site:

Type	Enzyme	Evidence	Notes
KINASE	PKACa (human)	pharmacological inhibitor of upstream enzyme, pharmacological activator of upstream enzyme

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
forskolin				increase
H-89				decrease

Downstream Regulation

Effect of modification (function): inhibition

S559-p - mucolipin 1 (human)

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