Curated Information
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Curated Information Page
PubMed Id: 17478428 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Mu JJ, et al. (2007) A proteomic analysis of ataxia telangiectasia-mutated (ATM)/ATM-Rad3-related (ATR) substrates identifies the ubiquitin-proteasome system as a regulator for DNA damage checkpoints. J Biol Chem 282, 17330-4 17478428
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
Download Sites

S26-p - BAT3 (human) ▲
Orthologous residues
BAT3 (human): S26‑p, BAT3 iso4 (human): S129‑p, BAT3 iso5 (human): ‑, BAT3 (mouse): S26‑p, BAT3 (rat): S26‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (human) modification site within consensus motif, activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
hydroxyurea increase

S218-p - BAT3 (human) ▲
Orthologous residues
BAT3 (human): S218‑p, BAT3 iso4 (human): S315‑p, BAT3 iso5 (human): ‑, BAT3 (mouse): S213‑p, BAT3 (rat): S212‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (human) modification site within consensus motif, activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
hydroxyurea increase

S556-p - FANCI (human) ▲
Orthologous residues
FANCI (human): S556‑p, FANCI (mouse): S555‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (human) modification site within consensus motif, activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
hydroxyurea increase

S559-p - FANCI (human) ▲
Orthologous residues
FANCI (human): S559‑p, FANCI (mouse): T558‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (human) modification site within consensus motif, activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
hydroxyurea increase

S730-p - FANCI (human) ▲
Orthologous residues
FANCI (human): S730‑p, FANCI (mouse): S729‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (human) modification site within consensus motif, activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
hydroxyurea increase

S972-p - FANCI (human) ▲
Orthologous residues
FANCI (human): S972‑p, FANCI (mouse): S968‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (human) modification site within consensus motif, activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
hydroxyurea increase

S1121-p - FANCI (human) ▲
Orthologous residues
FANCI (human): S1121‑p, FANCI (mouse): S1122‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (human) modification site within consensus motif, activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
hydroxyurea increase

S927-p - HUWE1 (human) ▲
Orthologous residues
HUWE1 (human): S927‑p, HUWE1 (mouse): S927‑p, HUWE1 (rat): ‑
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (human) modification site within consensus motif, activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
hydroxyurea increase

S2339-p - HUWE1 (human) ▲
Orthologous residues
HUWE1 (human): S2339‑p, HUWE1 (mouse): S2339‑p, HUWE1 (rat): S1072‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (human) modification site within consensus motif, activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
hydroxyurea increase

S2636-p - HUWE1 (human) ▲
Orthologous residues
HUWE1 (human): S2636‑p, HUWE1 (mouse): S2636‑p, HUWE1 (rat): S1369‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (human) modification site within consensus motif, activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
hydroxyurea increase

S3377-p - HUWE1 (human) ▲
Orthologous residues
HUWE1 (human): S3377‑p, HUWE1 (mouse): S3378‑p, HUWE1 (rat): S2111‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (human) modification site within consensus motif, activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
hydroxyurea increase

S3695-p - HUWE1 (human) ▲
Orthologous residues
HUWE1 (human): S3695‑p, HUWE1 (mouse): S3696‑p, HUWE1 (rat): S2429‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (human) modification site within consensus motif, activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
hydroxyurea increase

S3797-p - HUWE1 (human) ▲
Orthologous residues
HUWE1 (human): S3797‑p, HUWE1 (mouse): S3798‑p, HUWE1 (rat): S2531‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (human) modification site within consensus motif, activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
hydroxyurea increase

S816-p - MED1 (human) ▲
Orthologous residues
MED1 (human): S816‑p, MED1 (mouse): S816‑p, MED1 (rat): S801‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (human) modification site within consensus motif, activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
hydroxyurea increase

S872-p - MED1 (human) ▲
Orthologous residues
MED1 (human): S872‑p, MED1 (mouse): S872‑p, MED1 (rat): S857‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (human) modification site within consensus motif, activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
hydroxyurea increase

S874-p - MED1 (human) ▲
Orthologous residues
MED1 (human): S874‑p, MED1 (mouse): S874‑p, MED1 (rat): S859‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (human) modification site within consensus motif, activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
hydroxyurea increase

S887-p - MED1 (human) ▲
Orthologous residues
MED1 (human): S887‑p, MED1 (mouse): S887‑p, MED1 (rat): S872‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (human) modification site within consensus motif, activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
hydroxyurea increase

S953-p - MED1 (human) ▲
Orthologous residues
MED1 (human): S953‑p, MED1 (mouse): S953‑p, MED1 (rat): S938‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (human) modification site within consensus motif, activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
hydroxyurea increase

S1134-p - MED1 (human) ▲
Orthologous residues
MED1 (human): S1134‑p, MED1 (mouse): S1136‑p, MED1 (rat): S1120‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (human) modification site within consensus motif, activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
hydroxyurea increase

S1141-p - MED1 (human) ▲
Orthologous residues
MED1 (human): S1141‑p, MED1 (mouse): S1143‑p, MED1 (rat): S1127‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (human) modification site within consensus motif, activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
hydroxyurea increase

S1147-p - MED1 (human) ▲
Orthologous residues
MED1 (human): S1147‑p, MED1 (mouse): S1149‑p, MED1 (rat): S1133‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (human) modification site within consensus motif, activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
hydroxyurea increase

S403-p - RAD18 (human) ▲
Orthologous residues
RAD18 (human): S403‑p, RAD18 (mouse): P442‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (human) modification site within consensus motif, activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
hydroxyurea increase

S46-p - RFWD3 (human) ▲
Orthologous residues
RFWD3 (human): S46‑p, RFWD3 (mouse): S59‑p, RFWD3 (rat): S52‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (human) modification site within consensus motif, activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
hydroxyurea increase

S63-p - RFWD3 (human) ▲
Orthologous residues
RFWD3 (human): S63‑p, RFWD3 (mouse): S75‑p, RFWD3 (rat): S68‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (human) modification site within consensus motif, activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
hydroxyurea increase

S1851-p - RIF1 (human) ▲
Orthologous residues
RIF1 (human): S1851‑p, RIF1 (mouse): Q1820‑p, RIF1 (rat): Q1678‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (human) modification site within consensus motif, activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
hydroxyurea increase

S522-p - RNF20 (human) ▲
Orthologous residues
RNF20 (human): S522‑p, RNF20 (mouse): S522‑p, RNF20 (rat): S522‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (human) modification site within consensus motif, activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
hydroxyurea increase

S545-p - RNF20 (human) ▲
Orthologous residues
RNF20 (human): S545‑p, RNF20 (mouse): T545‑p, RNF20 (rat): T545‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (human) modification site within consensus motif, activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
hydroxyurea increase

S819-p - RNF40 (human) ▲
Orthologous residues
RNF40 (human): S819‑p, RNF40 (mouse): S819‑p, RNF40 (rat): S820‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (human) modification site within consensus motif, activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
hydroxyurea increase

S853-p - RNF40 (human) ▲
Orthologous residues
RNF40 (human): S853‑p, RNF40 (mouse): S853‑p, RNF40 (rat): S854‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (human) modification site within consensus motif, activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
hydroxyurea increase

S1138-p - SLX4 (human) ▲
Orthologous residues
SLX4 (human): S1138‑p, SLX4 (mouse): A943‑p, SLX4 (rat): A949‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (human) modification site within consensus motif, activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
hydroxyurea increase

S1271-p - SLX4 (human) ▲
Orthologous residues
SLX4 (human): S1271‑p, SLX4 (mouse): S1073‑p, SLX4 (rat): S1080‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (human) modification site within consensus motif, activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
hydroxyurea increase

S1631-p - SLX4 (human) ▲
Orthologous residues
SLX4 (human): S1631‑p, SLX4 (mouse): T1405‑p, SLX4 (rat): T1418‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (human) modification site within consensus motif, activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
hydroxyurea increase

S1716-p - SLX4 (human) ▲
Orthologous residues
SLX4 (human): S1716‑p, SLX4 (mouse): S1447‑p, SLX4 (rat): S1460‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (human) modification site within consensus motif, activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
hydroxyurea increase

S359-p - TAO3 (human) ▲
Orthologous residues
TAO3 (human): S359‑p, TAO3 (mouse): S359‑p, TAO3 (rat): S359‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (human) modification site within consensus motif, activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
hydroxyurea increase

S551-p - TAO3 (human) ▲
Orthologous residues
TAO3 (human): S551‑p, TAO3 (mouse): S551‑p, TAO3 (rat): S551‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (human) modification site within consensus motif, activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
hydroxyurea increase

S81-p - TDP1 (human) ▲
Orthologous residues
TDP1 (human): S81‑p, TDP1 (mouse): S81‑p, TDP1 (rat): S81‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (human) modification site within consensus motif, activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
hydroxyurea increase

S365-p - TDP1 (human) ▲
Orthologous residues
TDP1 (human): S365‑p, TDP1 (mouse): S366‑p, TDP1 (rat): S366‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (human) modification site within consensus motif, activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
hydroxyurea increase

S563-p - TDP1 (human) ▲
Orthologous residues
TDP1 (human): S563‑p, TDP1 (mouse): S564‑p, TDP1 (rat): S564‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (human) modification site within consensus motif, activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
hydroxyurea increase

S174-p - UBR5 (human) ▲
Orthologous residues
UBR5 (human): S174‑p, UBR5 (mouse): S174‑p, UBR5 (rat): S164‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (human) modification site within consensus motif, activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
hydroxyurea increase

S191-p - UBR5 (human) ▲
Orthologous residues
UBR5 (human): S191‑p, UBR5 (mouse): S191‑p, UBR5 (rat): S181‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (human) modification site within consensus motif, activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
hydroxyurea increase

S1532-p - UBR5 (human) ▲
Orthologous residues
UBR5 (human): S1532‑p, UBR5 (mouse): S1526‑p, UBR5 (rat): S1516‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (human) modification site within consensus motif, activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
hydroxyurea increase

S1679-p - UBR5 (human) ▲
Orthologous residues
UBR5 (human): S1679‑p, UBR5 (mouse): S1673‑p, UBR5 (rat): S1663‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (human) modification site within consensus motif, activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
hydroxyurea increase

S2586-p - UBR5 (human) ▲
Orthologous residues
UBR5 (human): S2586‑p, UBR5 (mouse): S2579‑p, UBR5 (rat): S2569‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (human) modification site within consensus motif, activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
hydroxyurea increase

S678-p - USP15 (human) ▲
Orthologous residues
USP15 (human): S678‑p, USP15 iso2 (human): S649‑p, USP15 (mouse): S678‑p, USP15 iso2 (mouse): S650‑p, USP15 (rat): S649‑p, USP15 iso2 (rat): S678‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (human) modification site within consensus motif, activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
hydroxyurea increase

S495-p - USP28 (human) ▲
Orthologous residues
USP28 (human): S495‑p, USP28 (mouse): S496‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (human) modification site within consensus motif, activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
hydroxyurea increase

S714-p - USP28 (human) ▲
Orthologous residues
USP28 (human): S714‑p, USP28 (mouse): S720‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (human) modification site within consensus motif, activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
hydroxyurea increase

S720-p - USP28 (human) ▲
Orthologous residues
USP28 (human): S720‑p, USP28 (mouse): S726‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (human) modification site within consensus motif, activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
hydroxyurea increase

S718-p - USP34 (human) ▲
Orthologous residues
USP34 (human): S718‑p, USP34 iso2 (human): S567‑p, USP34 (mouse): S744‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (human) modification site within consensus motif, activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
hydroxyurea increase

S1751-p - USP34 (human) ▲
Orthologous residues
USP34 (human): S1751‑p, USP34 iso2 (human): S1600‑p, USP34 (mouse): S1788‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (human) modification site within consensus motif, activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
hydroxyurea increase

S326-p - VCP (human) ▲
Orthologous residues
VCP (human): S326‑p, VCP (mouse): S326‑p, VCP (rat): S326‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (human) modification site within consensus motif, activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
hydroxyurea increase

S115-p - ZBTB2 (human) ▲
Orthologous residues
ZBTB2 (human): S115‑p, ZBTB2 (mouse): S115‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (human) modification site within consensus motif, activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
hydroxyurea increase


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