Curated Information
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Curated Information Page
PubMed Id: 17428986 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Alfa Cissé M, et al. (2007) M1 and M3 muscarinic receptors control physiological processing of cellular prion by modulating ADAM17 phosphorylation and activity. J Neurosci 27, 4083-92 17428986
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T735-p - TACE (mouse)
Orthologous residues
TACE (human): T735‑p, TACE (mouse): T735‑p, TACE (rat): T735‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial) [mAChR m1 (human)]
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
phorbol ester increase
phorbol ester, GF109203X inhibit treatment-induced increase
carbachol mAChR m1 (mouse) increase
carbachol, GF109203X inhibit treatment-induced increase


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