Curated Information
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Curated Information Page
PubMed Id: 19709933 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Di Virgilio M, Ying CY, Gautier J (2009) PIKK-dependent phosphorylation of Mre11 induces MRN complex inactivation by disassembly from chromatin. DNA Repair (Amst) 8, 1311-20 19709933
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
Download Sites

S264-p - MRE11A (human)
Orthologous residues
MRE11A (human): S264‑p, MRE11A iso2 (human): S264‑p, MRE11A (mouse): S264‑p, MRE11A (rat): S264‑p
Characterization
 Methods used to characterize site in vivo electrophoretic mobility shift, immunoprecipitation, mutation of modification site
 Relevant cell lines - cell types - tissues:  oocyte
 Cellular systems studied:  primary cells
 Species studied:  frog
 Comments:  based on mutation of multiple sites
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
okadaic acid, DSBs increase
caffeine DSBs, okadaic acid inhibit treatment-induced increase
KU-55933 DSBs, okadaic acid no effect upon treatment-induced increase
NU7026 DSBs, okadaic acid no effect upon treatment-induced increase
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
DNA Disrupts

T329-p - MRE11A (human)
Orthologous residues
MRE11A (human): T329‑p, MRE11A iso2 (human): T329‑p, MRE11A (mouse): T329‑p, MRE11A (rat): T329‑p
Characterization
 Methods used to characterize site in vivo electrophoretic mobility shift, immunoprecipitation, mutation of modification site
 Relevant cell lines - cell types - tissues:  oocyte
 Cellular systems studied:  primary cells
 Species studied:  frog
 Comments:  based on mutation of multiple sites
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
okadaic acid, DSBs increase
caffeine DSBs, okadaic acid inhibit treatment-induced increase
KU-55933 DSBs, okadaic acid no effect upon treatment-induced increase
NU7026 DSBs, okadaic acid no effect upon treatment-induced increase
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
DNA Disrupts

S382-p - MRE11A (human)
Orthologous residues
MRE11A (human): S382‑p, MRE11A iso2 (human): S382‑p, MRE11A (mouse): S382‑p, MRE11A (rat): S382‑p
Characterization
 Methods used to characterize site in vivo electrophoretic mobility shift, immunoprecipitation, mutation of modification site
 Relevant cell lines - cell types - tissues:  oocyte
 Cellular systems studied:  primary cells
 Species studied:  frog
 Comments:  based on mutation of multiple sites
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
okadaic acid, DSBs increase
caffeine DSBs, okadaic acid inhibit treatment-induced increase
KU-55933 DSBs, okadaic acid no effect upon treatment-induced increase
NU7026 DSBs, okadaic acid no effect upon treatment-induced increase
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
DNA Disrupts

T481-p - MRE11A (human)
Orthologous residues
MRE11A (human): T481‑p, MRE11A iso2 (human): T481‑p, MRE11A (mouse): T482‑p, MRE11A (rat): T482‑p
Characterization
 Methods used to characterize site in vivo electrophoretic mobility shift, immunoprecipitation, mutation of modification site
 Relevant cell lines - cell types - tissues:  oocyte
 Cellular systems studied:  primary cells
 Species studied:  frog
 Comments:  based on mutation of multiple sites
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
okadaic acid, DSBs increase
caffeine DSBs, okadaic acid inhibit treatment-induced increase
KU-55933 DSBs, okadaic acid no effect upon treatment-induced increase
NU7026 DSBs, okadaic acid no effect upon treatment-induced increase
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
DNA Disrupts

S531-p - MRE11A (human)
Orthologous residues
MRE11A (human): S531‑p, MRE11A iso2 (human): S531‑p, MRE11A (mouse): S532‑p, MRE11A (rat): S532‑p
Characterization
 Methods used to characterize site in vivo electrophoretic mobility shift, immunoprecipitation, mutation of modification site
 Relevant cell lines - cell types - tissues:  oocyte
 Cellular systems studied:  primary cells
 Species studied:  frog
 Comments:  based on mutation of multiple sites
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
okadaic acid, DSBs increase
caffeine DSBs, okadaic acid inhibit treatment-induced increase
KU-55933 DSBs, okadaic acid no effect upon treatment-induced increase
NU7026 DSBs, okadaic acid no effect upon treatment-induced increase
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
DNA Disrupts

S590-p - MRE11A (human)
Orthologous residues
MRE11A (human): S590‑p, MRE11A iso2 (human): S590‑p, MRE11A (mouse): S590‑p, MRE11A (rat): S590‑p
Characterization
 Methods used to characterize site in vivo electrophoretic mobility shift, immunoprecipitation, mutation of modification site
 Relevant cell lines - cell types - tissues:  oocyte
 Cellular systems studied:  primary cells
 Species studied:  frog
 Comments:  based on mutation of multiple sites
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
DNA Disrupts

S676-p - MRE11A (human)
Orthologous residues
MRE11A (human): S676‑p, MRE11A iso2 (human): S648‑p, MRE11A (mouse): S674‑p, MRE11A (rat): S674‑p
Characterization
 Methods used to characterize site in vivo electrophoretic mobility shift, immunoprecipitation, mutation of modification site
 Relevant cell lines - cell types - tissues:  oocyte
 Cellular systems studied:  primary cells
 Species studied:  frog
 Comments:  based on mutation of multiple sites
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
DNA Disrupts

S678-p - MRE11A (human)
Orthologous residues
MRE11A (human): S678‑p, MRE11A iso2 (human): S650‑p, MRE11A (mouse): S676‑p, MRE11A (rat): S676‑p
Characterization
 Methods used to characterize site in vivo electrophoretic mobility shift, immunoprecipitation, mutation of modification site
 Relevant cell lines - cell types - tissues:  oocyte
 Cellular systems studied:  primary cells
 Species studied:  frog
 Comments:  based on mutation of multiple sites
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
DNA Disrupts


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