Curated Information
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Curated Information Page
PubMed Id: 12930825 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Polgár J, et al. (2003) Phosphorylation of SNAP-23 in activated human platelets. J Biol Chem 278, 44369-76 12930825
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S23-p - SNAP23 (human) ▲
Orthologous residues
SNAP23 (human): S23‑p, SNAP23 (mouse): S23‑p, SNAP23 (rat): S23‑p
Characterization
 Methods used to characterize site in vivo:  mass spectrometry, mass spectrometry (in vitro), mutation of modification site, phosphoamino acid analysis
 Relevant cell lines - cell types - tissues:  platelet-blood
 Cellular systems studied:  cell lines, primary cells
 Species studied:  human
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE PKCA (rat)
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
STX4 (human) Induces molecular association, regulation in vitro

T24-p - SNAP23 (human) ▲
Orthologous residues
SNAP23 (human): T24‑p, SNAP23 (mouse): T24‑p, SNAP23 (rat): T24‑p
Characterization
 Methods used to characterize site in vivo:  mass spectrometry, mass spectrometry (in vitro), mutation of modification site, phosphoamino acid analysis
 Relevant cell lines - cell types - tissues:  platelet-blood
 Cellular systems studied:  cell lines, primary cells
 Species studied:  human
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE PKCA (rat)
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
STX4 (human) Induces molecular association, regulation in vitro

S95-p - SNAP23 (human) ▲
Orthologous residues
SNAP23 (human): S95‑p, SNAP23 (mouse): S95‑p, SNAP23 (rat): S95‑p
Characterization
 Methods used to characterize site in vivo:  mass spectrometry (in vitro)
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE PKCA (rat)

S161-p - SNAP23 (human) ▲
Orthologous residues
SNAP23 (human): S161‑p, SNAP23 (mouse): S160‑p, SNAP23 (rat): S160‑p
Characterization
 Methods used to characterize site in vivo:  mass spectrometry, mass spectrometry (in vitro), mutation of modification site, phosphoamino acid analysis
 Relevant cell lines - cell types - tissues:  platelet-blood
 Cellular systems studied:  cell lines, primary cells
 Species studied:  human
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE PKCA (rat)


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