Curated Information
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PubMed Id: 17431427 
Kasuno K, et al. (2007) Antagonism of p66shc by melanoma inhibitory activity. Cell Death Differ 14, 1414-21 17431427
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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S36-p - SHC1 (human)
Orthologous residues
SHC1 (human): S36‑p, SHC1 iso2 (human): , SHC1 iso3 (human): , SHC1 iso6 (human): , SHC1 iso7 (human): , SHC1 (mouse): S36‑p, SHC1 iso2 (mouse): , SHC1 iso3 (mouse): , SHC1 (rat): S36‑p, SHC1 iso2 (rat):
 Methods used to characterize site in vivo phospho-antibody
 Relevant cell lines - cell types - tissues:  B16 (melanocyte), COS (fibroblast), HMB2 (melanocyte), HMB2-5 (melanocyte)
 Cellular systems studied:  cell lines
 Species studied:  human, mink, mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
H2O2 increase
UV increase
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
MIA (human) Disrupts co-immunoprecipitation

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