Curated Information
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Curated Information Page
PubMed Id: 9391116 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Zhou YJ, et al. (1997) Distinct tyrosine phosphorylation sites in JAK3 kinase domain positively and negatively regulate its enzymatic activity. Proc Natl Acad Sci U S A 94, 13850-5 9391116
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y980-p - JAK3 (human) ▲
Orthologous residues
JAK3 (human): Y980‑p, JAK3 (mouse): Y976‑p, Jak3 iso2 (mouse): Y1195‑p, JAK3 iso3 (mouse): Y1189‑p, JAK3 (rat): Y976‑p
Characterization
 Methods used to characterize site in vivo:  electrophoretic mobility shift, mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  COS (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  monkey
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE JAK3 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE JAK3 (human) transfection of inactive enzyme
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced

Y981-p - JAK3 (human) ▲
Orthologous residues
JAK3 (human): Y981‑p, JAK3 (mouse): Y977‑p, Jak3 iso2 (mouse): Y1196‑p, JAK3 iso3 (mouse): Y1190‑p, JAK3 (rat): Y977‑p
Characterization
 Methods used to characterize site in vivo:  electrophoretic mobility shift, mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  COS (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  monkey
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE JAK3 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE JAK3 (human) transfection of inactive enzyme
Downstream Regulation
 Effect of modification (function):  enzymatic activity, inhibited


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