Curated Information
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Curated Information Page
PubMed Id: 19940129 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Yuan Z, et al. (2010) Phosphoinositide 3-kinase/Akt inhibits MST1-mediated pro-apoptotic signaling through phosphorylation of threonine 120. J Biol Chem 285, 3815-24 19940129
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T120-p - MST1 (human)
Orthologous residues
MST1 (human): T120‑p, MST1 (mouse): T120‑p, MST1 (rat): T120‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  ovarian cancer
 Relevant cell lines - cell types - tissues:  293 (epithelial), 293T (epithelial), COS (fibroblast), MEF (fibroblast), ovary
 Cellular systems studied:  cell lines, tissue
 Species studied:  human, monkey, mouse
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Akt1 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Akt1 (human) transfection of inactive enzyme, co-immunoprecipitation, phospho-motif antibody, transfection of wild-type enzyme, genetic knockout/knockin of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
IGF-1 increase
Downstream Regulation
 Effect of modification (function):  enzymatic activity, inhibited, intracellular localization, phosphorylation
 Effect of modification (process):  apoptosis, altered
 Comments:  regulates autophosphorylation of MST1 T183
Associated Diseases
Diseases: Alterations: Comments:
ovarian cancer increased

T183-p - MST1 (human)
Orthologous residues
MST1 (human): T183‑p, MST1 (mouse): T183‑p, MST1 (rat): T183‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  MEF (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE MST1 (human) activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Akt2 (human) increase siRNA Akt2
Akt1 (human) increase Akt1 -/- cells
Associated Diseases
Diseases: Alterations: Comments:
ovarian cancer decreased


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