Curated Information
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Curated Information Page
PubMed Id: 19891780 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Fernow I, Tomasovic A, Siehoff-Icking A, Tikkanen R (2009) Cbl-associated protein is tyrosine phosphorylated by c-Abl and c-Src kinases. BMC Cell Biol 10, 80 19891780
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y326-p - SORBS1 iso5 (mouse)
Orthologous residues
SORBS1 (human): Y536‑p, SORBS1 iso3 (human): Y421‑p, SORBS1 iso4 (human): Y326‑p, SORBS1 iso6 (human): Y404‑p, SORBS1 iso10 (human): Y458‑p, SORBS1 iso11 (human): Y490‑p, SORBS1 (mouse): Y325‑p, SORBS1 iso3 (mouse): Y316‑p, SORBS1 iso4 (mouse): Y356‑p, SORBS1 iso5 (mouse): Y326‑p, SORBS1 iso8 (mouse): Y496‑p, SORBS1 (rat): Y356‑p, SORBS1 iso2 (rat): Y325‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Src (human) transfection of inactive enzyme, transfection of wild-type enzyme, transfection of constitutively active enzyme
KINASE Abl (human) transfection of inactive enzyme, transfection of wild-type enzyme, modification site within consensus motif
Downstream Regulation
 Effect of modification (process):  cell motility, altered
 Comments:  mutation of this site inhibits cell spreading

Y360-p - SORBS1 iso5 (mouse)
Orthologous residues
SORBS1 (human): Y654‑p, SORBS1 iso3 (human): Y505‑p, SORBS1 iso4 (human): Y360‑p, SORBS1 iso6 (human): Y466‑p, SORBS1 iso10 (human): Y492‑p, SORBS1 iso11 (human): Y608‑p, SORBS1 (mouse): Y421‑p, SORBS1 iso3 (mouse): Y400‑p, SORBS1 iso4 (mouse): Y390‑p, SORBS1 iso5 (mouse): Y360‑p, SORBS1 iso8 (mouse): Y614‑p, SORBS1 (rat): Y390‑p, SORBS1 iso2 (rat): Y421‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Src (human) transfection of inactive enzyme, transfection of wild-type enzyme, transfection of constitutively active enzyme
KINASE Abl (human) transfection of inactive enzyme, transfection of wild-type enzyme, modification site within consensus motif

Y632-p - SORBS1 iso5 (mouse)
Orthologous residues
SORBS1 (human): Y1240‑p, SORBS1 iso3 (human): Y853‑p, SORBS1 iso4 (human): Y632‑p, SORBS1 iso6 (human): Y794‑p, SORBS1 iso10 (human): Y764‑p, SORBS1 iso11 (human): Y1214‑p, SORBS1 (mouse): Y1238‑p, SORBS1 iso3 (mouse): Y672‑p, SORBS1 iso4 (mouse): Y662‑p, SORBS1 iso5 (mouse): Y632‑p, SORBS1 iso8 (mouse): Y886‑p, SORBS1 (rat): Y662‑p, SORBS1 iso2 (rat): Y1238‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Abl (human) transfection of inactive enzyme, transfection of wild-type enzyme, modification site within consensus motif


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