Curated Information
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PubMed Id: 19917688 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Moreno-GarcĂ­a ME, et al. (2009) Serine 649 phosphorylation within the protein kinase C-regulated domain down-regulates CARMA1 activity in lymphocytes. J Immunol 183, 7362-70 19917688
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S564-p - CARD11 (mouse)
Orthologous residues
CARD11 (human): S559‑p, CARD11 (mouse): S564‑p, CARD11 (chicken): S575‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Disease tissue studied:  lymphoma, B cell lymphoma
 Relevant cell lines - cell types - tissues:  DT40 (B lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  chicken
Downstream Regulation
 Effect of modification (function):  activity, induced

S620-p - CARD11 (mouse)
Orthologous residues
CARD11 (human): S615‑p, CARD11 (mouse): S620‑p, CARD11 (chicken): S631‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  activity, inhibited

S649-p - CARD11 (mouse)
Orthologous residues
CARD11 (human): S644‑p, CARD11 (mouse): S649‑p, CARD11 (chicken): S660‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  lymphoma, B cell lymphoma, Burkitt's lymphoma
 Relevant cell lines - cell types - tissues:  293 (epithelial), DT40 (B lymphocyte), Jurkat (T lymphocyte), RAMOS (B lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  chicken, human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKCB (human) genetic knockout/knockin of upstream enzyme, pharmacological activator of upstream enzyme, pharmacological inhibitor of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anti-IgM increase
anti-CD3/CD28 increase
ionomycin, phorbol ester increase
rottlerin ionomycin, phorbol ester inhibit treatment-induced increase
Ro31-8425 ionomycin, phorbol ester inhibit treatment-induced increase
Downstream Regulation
 Effect of modification (function):  activity, inhibited
 Effect of modification (process):  apoptosis, altered, cell growth, altered

S657-p - CARD11 (mouse)
Orthologous residues
CARD11 (human): S652‑p, CARD11 (mouse): S657‑p, CARD11 (chicken): S668‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  lymphoma, B cell lymphoma
 Relevant cell lines - cell types - tissues:  DT40 (B lymphocyte), Jurkat (T lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  chicken, human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKCB (human) genetic knockout/knockin of upstream enzyme, pharmacological activator of upstream enzyme, pharmacological inhibitor of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anti-IgM increase
anti-CD3/CD28 increase
ionomycin, phorbol ester increase
rottlerin ionomycin, phorbol ester no effect upon treatment-induced increase
Ro31-8425 ionomycin, phorbol ester inhibit treatment-induced increase
Downstream Regulation
 Effect of modification (function):  activity, induced


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