Curated Information

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Curated Information Page

PubMed Id: 19837665

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Enomoto M, et al. (2009) Novel positive feedback loop between Cdk1 and Chk1 in the nucleus during G2/M transition. J Biol Chem 284, 34223-30 19837665

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

S286-p - Chk1 (mouse)

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Orthologous residues

Chk1 (human): S286‑p, Chk1 (mouse): S286‑p, Chk1 (rat): S286‑p, Chk1 (chicken): S286‑p

Characterization

Methods used to characterize site in vivo: immunoprecipitation, mutation of modification site, phospho-antibody, western blotting

Relevant cell lines - cell types - tissues: HeLa (cervical)

Cellular systems studied: cell lines

Species studied: human

Upstream Regulation

Potential in vivo enzymes for site:

Type	Enzyme	Evidence	Notes
KINASE	CDK1 (human)	activation of upstream enzyme, transfection of wild-type enzyme

Downstream Regulation

Effect of modification (function): intracellular localization

S301-p - Chk1 (mouse)

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