Curated Information
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Curated Information Page
PubMed Id: 19837665 
Enomoto M, et al. (2009) Novel positive feedback loop between Cdk1 and Chk1 in the nucleus during G2/M transition. J Biol Chem 284, 34223-30 19837665
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S286-p - Chk1 (mouse)
Orthologous residues
Chk1 (human): S286‑p, Chk1 (mouse): S286‑p, Chk1 (rat): S286‑p, Chk1 (chicken): S286‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE CDK1 (human) activation of upstream enzyme, transfection of wild-type enzyme
Downstream Regulation
 Effect of modification (function):  intracellular localization

S301-p - Chk1 (mouse)
Orthologous residues
Chk1 (human): S301‑p, Chk1 (mouse): S301‑p, Chk1 (rat): S301‑p, Chk1 (chicken): S301‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE CDK1 (human) activation of upstream enzyme, transfection of wild-type enzyme
Downstream Regulation
 Effect of modification (function):  intracellular localization


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