Curated Information
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Curated Information Page
PubMed Id: 11598104 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Jakobsen SN, Hardie DG, Morrice N, Tornqvist HE (2001) 5'-AMP-activated protein kinase phosphorylates IRS-1 on Ser-789 in mouse C2C12 myotubes in response to 5-aminoimidazole-4-carboxamide riboside. J Biol Chem 276, 46912-6 11598104
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S789-p - IRS1 (mouse) ▲
Orthologous residues
IRS1 (human): S794‑p, IRS1 (mouse): S789‑p, IRS1 (rat): S789‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  C2C12 (myoblast)
 Cellular systems studied:  cell lines
 Species studied:  mouse
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE AMPKA1 (rat)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
AICAR increase
wortmannin AICAR no effect upon treatment-induced increase
insulin AICAR no effect upon treatment-induced increase
insulin no change compared to control


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