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PubMed Id: 19887368 
Wang P, et al. (2010) Functional characterization of the kinase activation loop in nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) using tandem affinity purification and liquid chromatography-mass spectrometry. J Biol Chem 285, 95-103 19887368
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y138-p - NPM-ALK (human)
Orthologous residues
NPM‑ALK (human): Y138‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  GP293 (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Comments:  regulates cell viability

Y152-p - NPM-ALK (human)
Orthologous residues
NPM‑ALK (human): Y152‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  GP293 (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  human

Y156-p - NPM-ALK (human)
Orthologous residues
NPM‑ALK (human): Y156‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  GP293 (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Comments:  regulates cell viability

Y191-p - NPM-ALK (human)
Orthologous residues
NPM‑ALK (human): Y191‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  GP293 (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  human

Y338-p - NPM-ALK (human)
Orthologous residues
NPM‑ALK (human): Y338‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mass spectrometry, mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  GP293 (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced

Y342-p - NPM-ALK (human)
Orthologous residues
NPM‑ALK (human): Y342‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mass spectrometry, mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  GP293 (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced

Y343-p - NPM-ALK (human)
Orthologous residues
NPM‑ALK (human): Y343‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mass spectrometry, mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  GP293 (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced

Y419-p - NPM-ALK (human)
Orthologous residues
NPM‑ALK (human): Y419‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  GP293 (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  human

Y567-p - NPM-ALK (human)
Orthologous residues
NPM‑ALK (human): Y567‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  GP293 (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Comments:  regulates cell viability

Y644-p - NPM-ALK (human)
Orthologous residues
NPM‑ALK (human): Y644‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  GP293 (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Comments:  regulates cell viability

Y664-p - NPM-ALK (human)
Orthologous residues
NPM‑ALK (human): Y664‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Relevant cell lines - cell types - tissues:  GP293 (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  human


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