Curated Information
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Curated Information Page
PubMed Id: 19876919 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Siu MK, et al. (2010) Differential expression and phosphorylation of Pak1 and Pak2 in ovarian cancer: effects on prognosis and cell invasion. Int J Cancer 127, 21-31 19876919
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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T212-p - PAK1 (human) ▲
Orthologous residues
PAK1 (human): T212‑p, PAK1 (mouse): T212‑p, PAK1 (rat): T211‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Disease tissue studied:  ovarian cancer
 Relevant cell lines - cell types - tissues:  OVCAR3 (ovarian), OVCAR420 (ovarian), SKOV-3 (ovarian)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
HGF increase
Associated Diseases
Diseases: Alterations: Comments:
ovarian cancer increased

T423-p - PAK1 (human) ▲
Orthologous residues
PAK1 (human): T423‑p, PAK1 (mouse): T423‑p, PAK1 (rat): T422‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Disease tissue studied:  ovarian cancer
 Relevant cell lines - cell types - tissues:  OVCAR3 (ovarian), OVCAR420 (ovarian), SKOV-3 (ovarian)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
HGF increase
Associated Diseases
Diseases: Alterations: Comments:
ovarian cancer increased

S20-p - PAK2 (human) ▲
Orthologous residues
PAK2 (human): S20‑p, PAK2 (mouse): S20‑p, PAK2 (rat): S20‑p, PAK2 (rabbit): S20‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Disease tissue studied:  ovarian cancer
 Relevant cell lines - cell types - tissues:  OVCAR3 (ovarian)
 Cellular systems studied:  cell lines
 Species studied:  human
Associated Diseases
Diseases: Alterations: Comments:
ovarian cancer increased


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