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Orthologous residues
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CENPA (human): S7‑p, CENPA (mouse): ‑, CENPA (rat): ‑
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Characterization
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Methods used to characterize site in vivo:
[32P] bio-synthetic labeling, microscopy-colocalization with upstream kinase, mutation of modification site, phospho-antibody
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Relevant cell lines - cell types - tissues:
HeLa (cervical)
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Cellular systems studied:
cell lines
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Species studied:
human
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Enzymes shown to modify site in vitro:
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Downstream Regulation
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Effect of modification (function):
intracellular localization
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Effect of modification (process):
cell cycle regulation, chromatin organization, altered
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Comments:
Aurora B, INCEP and PP1gamma are mislocalized during anaphase in mitosis in mutants.
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