Curated Information
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Curated Information Page
PubMed Id: 11756469 
Zeitlin SG, Shelby RD, Sullivan KF (2001) CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis. J Cell Biol 155, 1147-57 11756469
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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S7-p - CENPA (human)
Orthologous residues
CENPA (human): S7‑p, CENPA (mouse): , CENPA (rat):
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, microscopy-colocalization with upstream kinase, mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE AurB (human)
Downstream Regulation
 Effect of modification (function):  intracellular localization
 Effect of modification (process):  cell cycle regulation, chromatin organization, altered
 Comments:  Aurora B, INCEP and PP1gamma are mislocalized during anaphase in mitosis in mutants.


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