Curated Information

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Curated Information Page

PubMed Id: 11278469

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Cong M, et al. (2001) Regulation of membrane targeting of the G protein-coupled receptor kinase 2 by protein kinase A and its anchoring protein AKAP79. J Biol Chem 276, 15192-9 11278469

S685-p - GRK2 (cow)

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Orthologous residues

GRK2 (human): S685‑p, GRK2 (mouse): S685‑p, GRK2 (rat): S685‑p, GRK2 (cow): S685‑p

Characterization

Methods used to characterize site in vivo: [32P] bio-synthetic labeling, mutation of modification site

Relevant cell lines - cell types - tissues: 293 (epithelial)

Cellular systems studied: cell lines

Species studied: human

Enzymes shown to modify site in vitro:

Type	Enzyme
KINASE	PKACA (human)

Downstream Regulation

Effect of modification (function): molecular association, regulation

Modification regulates interactions with:

Interacting molecule	Interacting domains	Effect	Consequences (function)	Consequences (process)	Detection assays
ADRB2 (human)		Induces	phosphorylation, receptor internalization, altered		co-immunoprecipitation

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