Curated Information
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Curated Information Page
PubMed Id: 9890893 
Lehr S, et al. (1999) Identification of tyrosine phosphorylation sites in human Gab-1 protein by EGF receptor kinase in vitro. Biochemistry 38, 151-9 9890893
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y285-p - Gab1 (human)
Orthologous residues
Gab1 (human): Y285‑p, Gab1 iso2 (human): Y285‑p, Gab1 (mouse): Y285‑p, Gab1 (rat): Y284‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE EGFR (human)

Y373-p - Gab1 (human)
Orthologous residues
Gab1 (human): Y373‑p, Gab1 iso2 (human): Y373‑p, Gab1 (mouse): Y373‑p, Gab1 (rat): Y372‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE EGFR (human)

Y406-p - Gab1 (human)
Orthologous residues
Gab1 (human): Y406‑p, Gab1 iso2 (human): Y406‑p, Gab1 (mouse): Y407‑p, Gab1 (rat): Y405‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE EGFR (human)

Y447-p - Gab1 (human)
Orthologous residues
Gab1 (human): Y447‑p, Gab1 iso2 (human): Y447‑p, Gab1 (mouse): Y448‑p, Gab1 (rat): Y446‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE EGFR (human)

Y472-p - Gab1 (human)
Orthologous residues
Gab1 (human): Y472‑p, Gab1 iso2 (human): Y472‑p, Gab1 (mouse): Y473‑p, Gab1 (rat): Y471‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE EGFR (human)

Y589-p - Gab1 (human)
Orthologous residues
Gab1 (human): Y589‑p, Gab1 iso2 (human): Y619‑p, Gab1 (mouse): Y590‑p, Gab1 (rat): Y588‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE EGFR (human)

Y627-p - Gab1 (human)
Orthologous residues
Gab1 (human): Y627‑p, Gab1 iso2 (human): Y657‑p, Gab1 (mouse): Y628‑p, Gab1 (rat): Y626‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE EGFR (human)
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
SYP (human) Induces pull-down assay

Y659-p - Gab1 (human)
Orthologous residues
Gab1 (human): Y659‑p, Gab1 iso2 (human): Y689‑p, Gab1 (mouse): Y660‑p, Gab1 (rat): Y658‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE EGFR (human)


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