Curated Information
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Curated Information Page
PubMed Id: 10734310 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Gual P, et al. (2000) Sustained recruitment of phospholipase C-gamma to Gab1 is required for HGF-induced branching tubulogenesis. Oncogene 19, 1509-18 10734310
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y285-p - Gab1 (mouse) ▲
Orthologous residues
Gab1 (human): Y285‑p, Gab1 iso2 (human): Y285‑p, Gab1 (mouse): Y285‑p, Gab1 (rat): Y285‑p
Characterization
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE EGFR (mouse)
KINASE Met (mouse)

Y307-p - Gab1 (mouse) ▲
Orthologous residues
Gab1 (human): Y307‑p, Gab1 iso2 (human): Y307‑p, Gab1 (mouse): Y307‑p, Gab1 (rat): Y307‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial), COS (fibroblast), MDCK (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  dog, human, monkey
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE Met (mouse)
KINASE EGFR (mouse)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
EGF increase
HGF increase
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  cell differentiation, altered, cell growth, altered
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
PLCG1 (mouse) Induces pull-down assay, co-immunoprecipitation

Y373-p - Gab1 (mouse) ▲
Orthologous residues
Gab1 (human): Y373‑p, Gab1 iso2 (human): Y373‑p, Gab1 (mouse): Y373‑p, Gab1 (rat): Y373‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial), COS (fibroblast), MDCK (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  dog, human, monkey
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE EGFR (mouse)
KINASE Met (mouse)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
EGF increase
HGF increase
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  cell differentiation, altered, cell growth, altered
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
PLCG1 (mouse) Induces cytoskeletal reorganization pull-down assay, co-immunoprecipitation

Y407-p - Gab1 (mouse) ▲
Orthologous residues
Gab1 (human): Y406‑p, Gab1 iso2 (human): Y406‑p, Gab1 (mouse): Y407‑p, Gab1 (rat): Y406‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial), COS (fibroblast), MDCK (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  dog, human, monkey
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE Met (mouse)
KINASE EGFR (mouse)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
EGF increase
HGF increase
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  cell differentiation, altered, cell growth, altered
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
PLCG1 (mouse) Induces cytoskeletal reorganization pull-down assay, co-immunoprecipitation

Y448-p - Gab1 (mouse) ▲
Orthologous residues
Gab1 (human): Y447‑p, Gab1 iso2 (human): Y447‑p, Gab1 (mouse): Y448‑p, Gab1 (rat): Y447‑p
Characterization
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE EGFR (mouse)
KINASE Met (mouse)

Y473-p - Gab1 (mouse) ▲
Orthologous residues
Gab1 (human): Y472‑p, Gab1 iso2 (human): Y472‑p, Gab1 (mouse): Y473‑p, Gab1 (rat): Y472‑p
Characterization
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE Met (mouse)
KINASE EGFR (mouse)

Y590-p - Gab1 (mouse) ▲
Orthologous residues
Gab1 (human): Y589‑p, Gab1 iso2 (human): Y619‑p, Gab1 (mouse): Y590‑p, Gab1 (rat): Y589‑p
Characterization
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE Met (mouse)
KINASE EGFR (mouse)

Y628-p - Gab1 (mouse) ▲
Orthologous residues
Gab1 (human): Y627‑p, Gab1 iso2 (human): Y657‑p, Gab1 (mouse): Y628‑p, Gab1 (rat): Y627‑p
Characterization
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE Met (mouse)
KINASE EGFR (mouse)

Y660-p - Gab1 (mouse) ▲
Orthologous residues
Gab1 (human): Y659‑p, Gab1 iso2 (human): Y689‑p, Gab1 (mouse): Y660‑p, Gab1 (rat): Y659‑p
Characterization
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE Met (mouse)
KINASE EGFR (mouse)


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