Curated Information
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Curated Information Page
PubMed Id: 19783980 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Dawson MA, et al. (2009) JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin. Nature 461, 819-22 19783980
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Y42-p - H3 (human)
Orthologous residues
H3 (human): Y42‑p, H3 (mouse): Y42‑p, H3 iso2 (mouse): Y42‑p, H3 iso3 (mouse): Y42‑p, H3 (rat): Y42‑p, H3 iso3 (rat): Y42‑p, H3 (pig): Y42‑p, H3 (chicken): Y42‑p, H3 (cow): Y42‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Disease tissue studied:  leukemia, chronic myelogenous leukemia, erythroid leukemia
 Relevant cell lines - cell types - tissues:  HEL (erythroid), K562 (erythroid), SET2, UKE1
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE JAK2 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE JAK2 (human) pharmacological inhibitor of upstream enzyme, transfection of wild-type enzyme, transfection of constitutively active enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
LIF increase
PDGF increase
TG101209 decrease
AT9283 decrease
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  chromatin organization, altered
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
HP1 alpha (human) CSD Disrupts in vitro


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