Curated Information
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PubMed Id: 19783980 
Dawson MA, et al. (2009) JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin. Nature 461, 819-22 19783980
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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Y41-p - H3 (human)
Orthologous residues
H3 (human): Y41‑p, H3 (mouse): Y41‑p, H3 iso2 (mouse): Y41‑p, H3 iso3 (mouse): Y41‑p, H3 (rat): Y41‑p, H3 iso3 (rat): Y41‑p, H3 (pig): Y41‑p, H3 (chicken): Y41‑p, H3 (cow): Y41‑p
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Disease tissue studied:  leukemia, chronic myelogenous leukemia, erythroid leukemia
 Relevant cell lines - cell types - tissues:  HEL (erythroid), K562 (erythroid), SET2, UKE1
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE JAK2 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE JAK2 (human) transfection of wild-type enzyme, transfection of constitutively active enzyme, pharmacological inhibitor of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
LIF increase
PDGF increase
TG101209 decrease
AT9283 decrease
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  chromatin organization, altered
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
HP1 alpha (human) CSD Disrupts in vitro

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