Curated Information

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Curated Information Page

PubMed Id: 10377409

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Gautreau A, Poullet P, Louvard D, Arpin M (1999) Ezrin, a plasma membrane-microfilament linker, signals cell survival through the phosphatidylinositol 3-kinase/Akt pathway. Proc Natl Acad Sci U S A 96, 7300-5 10377409

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

S473-p - Akt1 (human)

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Orthologous residues

Akt1 (human): S473‑p, Akt1 (mouse): S473‑p, Akt1 (rat): S473‑p, Akt1 (fruit fly): S586‑p, Akt1 (cow): S473‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody

Relevant cell lines - cell types - tissues: LLC-PK1 (epithelial)

Cellular systems studied: cell lines

Species studied: pig

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
LY294002				decrease

Downstream Regulation

Effect of modification (function): enzymatic activity, induced

Effect of modification (process): apoptosis, inhibited

Y354-p - ezrin (human)

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Orthologous residues

ezrin (human): Y354‑p, ezrin (mouse): Y354‑p, ezrin (rat): F354‑p

Characterization

Methods used to characterize site in vivo: mutation of modification site

Relevant cell lines - cell types - tissues: LLC-PK1 (epithelial) [ezrin (human)]

Cellular systems studied: cell lines

Species studied: pig

Downstream Regulation

Effect of modification (function): molecular association, regulation

Modification regulates interactions with:

Interacting molecule	Interacting domains	Effect	Consequences (function)	Consequences (process)	Detection assays
PIK3R1 (human)	SH2	Induces		apoptosis, altered	co-immunoprecipitation

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