Curated Information
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Curated Information Page
PubMed Id: 10377409 
Gautreau A, Poullet P, Louvard D, Arpin M (1999) Ezrin, a plasma membrane-microfilament linker, signals cell survival through the phosphatidylinositol 3-kinase/Akt pathway. Proc Natl Acad Sci U S A 96, 7300-5 10377409
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Click on the protein name to open the protein page, and on the RSD number to open the site page.
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S473-p - Akt1 (human)
Orthologous residues
Akt1 (human): S473‑p, Akt1 (mouse): S473‑p, Akt1 (rat): S473‑p, Akt1 (fruit fly): S586‑p, Akt1 (cow): S473‑p
 Methods used to characterize site in vivo phospho-antibody
 Relevant cell lines - cell types - tissues:  LLC-PK1 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  pig
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
LY294002 decrease
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced
 Effect of modification (process):  apoptosis, inhibited

Y354-p - Ezrin (human)
Orthologous residues
Ezrin (human): Y354‑p, Ezrin (mouse): Y354‑p, Ezrin (rat): F354‑p
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  LLC-PK1 (epithelial) [Ezrin (human)]
 Cellular systems studied:  cell lines
 Species studied:  pig
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
PIK3R1 (human) SH2 Induces apoptosis, altered co-immunoprecipitation

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