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Orthologous residues
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|
HER2 (human): Y1112‑p, HER2 iso2 (human): Y502‑p, HER2 (mouse): Y1113‑p, HER2 (rat): Y1114‑p
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Characterization
|
|
Methods used to characterize site in vivo:
mutation of modification site
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|
Relevant cell lines - cell types - tissues:
293T (epithelial), CHO (fibroblast)
|
|
Cellular systems studied:
cell lines
|
|
Species studied:
hamster, human
|
|
Downstream Regulation
|
|
Effect of modification (function):
molecular association, regulation, protein degradation
|
|
Modification regulates interactions with:
|
|
Interacting molecule
|
Interacting domains
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Effect
|
Consequences (function)
|
Consequences (process)
|
Detection assays
|
|
Cbl (human)
|
|
Induces
|
|
|
co-immunoprecipitation
|
|
