Curated Information

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Curated Information Page

PubMed Id: 9880482

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Ahn S, et al. (1999) Src-mediated tyrosine phosphorylation of dynamin is required for beta2-adrenergic receptor internalization and mitogen-activated protein kinase signaling. J Biol Chem 274, 1185-8 9880482

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

Y231-p - DYN1 (rat)

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Orthologous residues

DYN1 (human): Y231‑p, DYN1 (mouse): Y231‑p, DYN1 iso3 (mouse): Y231‑p, DYN1 iso4 (mouse): Y231‑p, DYN1 iso6 (mouse): Y231‑p, DYN1 (rat): Y231‑p, DYN1 iso2 (rat): Y231‑p

Characterization

Methods used to characterize site in vivo: [32P] bio-synthetic labeling, immunoprecipitation, mutation of modification site, western blotting

Relevant cell lines - cell types - tissues: 293 (epithelial)

Cellular systems studied: cell lines

Species studied: human

Upstream Regulation

Potential in vivo enzymes for site:

Type	Enzyme	Evidence	Notes
KINASE	Src (rat)	transfection of inactive enzyme, transfection of constitutively active enzyme

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
isoproterenol				increase

Downstream Regulation

Effect of modification (function): inhibition, molecular association, regulation, receptor internalization, altered

Comments: Y231/597F mutant Inhibits B2-AR internalization, and inhibited the isoproterenol mediated activation of ERK2.

Y597-p - DYN1 (rat)

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