Curated Information
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Curated Information Page
PubMed Id: 9880482 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Ahn S, et al. (1999) Src-mediated tyrosine phosphorylation of dynamin is required for beta2-adrenergic receptor internalization and mitogen-activated protein kinase signaling. J Biol Chem 274, 1185-8 9880482
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y231-p - DYN1 (rat)
Orthologous residues
DYN1 (human): Y231‑p, DYN1 (mouse): Y231‑p, DYN1 iso3 (mouse): Y231‑p, DYN1 iso4 (mouse): Y231‑p, DYN1 iso6 (mouse): Y231‑p, DYN1 (rat): Y231‑p, DYN1 iso2 (rat): Y231‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, immunoprecipitation, mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Src (rat) transfection of constitutively active enzyme, transfection of inactive enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
isoproterenol increase
Downstream Regulation
 Effect of modification (function):  activity, inhibited, molecular association, regulation, receptor internalization, altered
 Comments:  Y231/597F mutant Inhibits B2-AR internalization, and inhibited the isoproterenol mediated activation of ERK2.

Y597-p - DYN1 (rat)
Orthologous residues
DYN1 (human): Y597‑p, DYN1 (mouse): Y597‑p, DYN1 iso3 (mouse): Y597‑p, DYN1 iso4 (mouse): Y597‑p, DYN1 iso6 (mouse): Y593‑p, DYN1 (rat): Y597‑p, DYN1 iso2 (rat): Y597‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, immunoprecipitation, mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Src (rat) transfection of constitutively active enzyme, transfection of inactive enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
isoproterenol increase
Downstream Regulation
 Effect of modification (function):  activity, inhibited, molecular association, regulation, receptor internalization, altered
 Comments:  Y231/597F mutant Inhibits B2-AR internalization, and inhibited the isoproterenol mediated activation of ERK2.


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