Curated Information
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Curated Information Page
PubMed Id: 10910365 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Li S, et al. (2000) Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response. Nature 406, 210-5 10910365
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
Download Sites

S664-p - CtIP (human)
Orthologous residues
CtIP (human): S664‑p, CtIP iso3 (human): S664‑p, CtIP (mouse): S662‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, electrophoretic mobility shift, immunoprecipitation, mutation of modification site
 Relevant cell lines - cell types - tissues:  GM00637 (fibroblast), GM09607 (fibroblast), T24 (bladder cell)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (human) mutation in upstream enzyme recognition motif, activation of upstream enzyme, transfection of dominant-negative enzyme, co-immunoprecipitation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
UV no change compared to control
MMS no change compared to control
ionizing radiation increase
wortmannin ionizing radiation inhibit treatment-induced increase
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
BRCA1 (human) Disrupts

S745-p - CtIP (human)
Orthologous residues
CtIP (human): S745‑p, CtIP iso3 (human): S745‑p, CtIP (mouse): S742‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, electrophoretic mobility shift, immunoprecipitation, mutation of modification site
 Relevant cell lines - cell types - tissues:  GM00637 (fibroblast), GM09607 (fibroblast), T24 (bladder cell)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (human) mutation in upstream enzyme recognition motif, activation of upstream enzyme, transfection of dominant-negative enzyme, co-immunoprecipitation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
UV no change compared to control
MMS no change compared to control
ionizing radiation increase
wortmannin ionizing radiation inhibit treatment-induced increase
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
BRCA1 (human) Disrupts


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