Curated Information
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PubMed Id: 12881528 
Dixelius J, et al. (2003) Ligand-induced vascular endothelial growth factor receptor-3 (VEGFR-3) heterodimerization with VEGFR-2 in primary lymphatic endothelial cells regulates tyrosine phosphorylation sites. J Biol Chem 278, 40973-9 12881528
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
Download Sites

Y1230-p - VEGFR3 (mouse)
Orthologous residues
VEGFR3 (human): Y1230‑p, VEGFR3 (mouse): Y1230‑p, VEGFR3 (rat): Y1230‑p
Characterization
 Methods used to characterize site in vivo 2D analysis, immunoprecipitation, mutation of modification site, phosphoamino acid analysis, phosphopeptide mapping, western blotting
 Relevant cell lines - cell types - tissues:  293 (epithelial), endothelial, PAE (endothelial)
 Cellular systems studied:  cell lines
 Species studied:  human, pig
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE VEGFR2 (mouse) transfection of wild-type enzyme, phosphopeptide analysis
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
VEGF increase

Y1231-p - VEGFR3 (mouse)
Orthologous residues
VEGFR3 (human): Y1231‑p, VEGFR3 (mouse): Y1231‑p, VEGFR3 (rat): Y1231‑p
Characterization
 Methods used to characterize site in vivo 2D analysis, immunoprecipitation, mutation of modification site, phosphoamino acid analysis, phosphopeptide mapping, western blotting
 Relevant cell lines - cell types - tissues:  293 (epithelial), endothelial, PAE (endothelial)
 Cellular systems studied:  cell lines
 Species studied:  human, pig
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE VEGFR2 (mouse) transfection of wild-type enzyme, phosphopeptide analysis
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
VEGF increase

Y1265-p - VEGFR3 (mouse)
Orthologous residues
VEGFR3 (human): Y1265‑p, VEGFR3 (mouse): Y1265‑p, VEGFR3 (rat): Y1265‑p
Characterization
 Methods used to characterize site in vivo 2D analysis, immunoprecipitation, mutation of modification site, phosphoamino acid analysis, phosphopeptide mapping, western blotting
 Relevant cell lines - cell types - tissues:  293 (epithelial), endothelial, PAE (endothelial)
 Cellular systems studied:  cell lines
 Species studied:  human, pig
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE VEGFR2 (mouse) transfection of wild-type enzyme, phosphopeptide analysis
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
VEGF increase

Y1333-p - VEGFR3 (mouse)
Orthologous residues
VEGFR3 (human): Y1333‑p, VEGFR3 (mouse): Y1333‑p, VEGFR3 (rat): Y1333‑p
Characterization
 Methods used to characterize site in vivo 2D analysis, immunoprecipitation, mutation of modification site, phosphoamino acid analysis, phosphopeptide mapping, western blotting
 Relevant cell lines - cell types - tissues:  293 (epithelial), endothelial, PAE (endothelial)
 Cellular systems studied:  cell lines
 Species studied:  human, pig

Y1337-p - VEGFR3 (mouse)
Orthologous residues
VEGFR3 (human): Y1337‑p, VEGFR3 (mouse): Y1337‑p, VEGFR3 (rat): Y1337‑p
Characterization
 Methods used to characterize site in vivo 2D analysis, immunoprecipitation, mutation of modification site, phosphoamino acid analysis, phosphopeptide mapping, western blotting
 Relevant cell lines - cell types - tissues:  293 (epithelial), endothelial, PAE (endothelial)
 Cellular systems studied:  cell lines
 Species studied:  human, pig
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
VEGF increase

Y1363-p - VEGFR3 (mouse)
Orthologous residues
VEGFR3 (human): Y1363‑p, VEGFR3 (mouse): Y1363‑p, VEGFR3 (rat): Y1363‑p
Characterization
 Methods used to characterize site in vivo 2D analysis, immunoprecipitation, mutation of modification site, phosphoamino acid analysis, phosphopeptide mapping, western blotting
 Relevant cell lines - cell types - tissues:  293 (epithelial), endothelial, PAE (endothelial)
 Cellular systems studied:  cell lines
 Species studied:  human, pig
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
VEGF increase


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