Curated Information
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Curated Information Page
PubMed Id: 12805220 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Baas AF, et al. (2003) Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD. EMBO J 22, 3062-72 12805220
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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T185-p - LKB1 (human)
Orthologous residues
LKB1 (human): T185‑p, LKB1 iso2 (human): T185‑p, LKB1 (mouse): T185‑p, LKB1 (rat): T185‑p, LKB1 (pig): T91‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE LKB1 (human)
 Comments:  autophosphorylation
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced
 Comments:  STRAD increases LKB1 activation

T336-p - LKB1 (human)
Orthologous residues
LKB1 (human): T336‑p, LKB1 iso2 (human): T336‑p, LKB1 (mouse): T336‑p, LKB1 (rat): T336‑p, LKB1 (pig): T242‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE LKB1 (human)
 Comments:  autophosphorylation
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced
 Comments:  STRAD increases LKB1 activation

T363-p - LKB1 (human)
Orthologous residues
LKB1 (human): T363‑p, LKB1 iso2 (human): T363‑p, LKB1 (mouse): T366‑p, LKB1 (rat): T366‑p, LKB1 (pig): T271‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE LKB1 (human)
 Comments:  autophosphorylation
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced
 Comments:  STRAD increases LKB1 activation

T402-p - LKB1 (human)
Orthologous residues
LKB1 (human): T402‑p, LKB1 iso2 (human): , LKB1 (mouse): S404‑p, LKB1 (rat): S404‑p, LKB1 (pig): A310‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE LKB1 (human)
 Comments:  autophosphorylation
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced
 Comments:  STRAD increases LKB1 activation

T329-p - STRAD (human)
Orthologous residues
STRAD (human): T329‑p, STRAD (mouse): A329‑p, STRAD (rat): A291‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE LKB1 (human)

T419-p - STRAD (human)
Orthologous residues
STRAD (human): T419‑p, STRAD (mouse): T419‑p, STRAD (rat): T381‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE LKB1 (human)

T65-p - MBP (rabbit)
Orthologous residues
MBP (human): A201‑p, MBP iso3 (human): A94‑p, MBP iso4 (human): A94‑p, MBP iso5 (human): A68‑p, MBP (mouse): T197‑p, MBP iso5 (mouse): T64‑p, MBP iso6 (mouse): T90‑p, MBP iso8 (mouse): T64‑p, MBP iso10 (mouse): T64‑p, MBP (rat): T92‑p, MBP (rabbit): T65‑p, MBP (chicken): S65‑p, MBP (cow): T65‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE LKB1 (human)


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