Curated Information
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Curated Information Page
PubMed Id: 12023960 
Lizcano JM, et al. (2002) Molecular basis for the substrate specificity of NIMA-related kinase-6 (NEK6). Evidence that NEK6 does not phosphorylate the hydrophobic motif of ribosomal S6 protein kinase and serum- and glucocorticoid-induced protein kinase in vivo. J Biol Chem 277, 27839-49 12023960
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S161-p - CDK7 (human)
Orthologous residues
CDK7 (human): S161‑p, CDK7 (mouse): S161‑p, CDK7 (rat): S153‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE NEK6 (human)

S788-p - DDR1 (human)
Orthologous residues
DDR1 (human): S788‑p, DDR1 (mouse): S786‑p, DDR1 (rat): S785‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE NEK6 (human)

S890-p - NMDAR1 (human)
Orthologous residues
NMDAR1 (human): S890‑p, NMDAR1 iso2 (human): , NMDAR1 iso5 (human): S911‑p, NMDAR1 (mouse): S890‑p, NMDAR1 iso2 (mouse): , NMDAR1 iso3 (mouse): S911‑p, NMDAR1 (rat): S890‑p, NMDAR1 iso7 (rat):
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE NEK6 (human)

S53-p - p70S6K (human)
Orthologous residues
p70S6K (human): S53‑p, p70S6K iso2 (human): S30‑p, p70S6K (mouse): S53‑p, p70S6K (rat): S53‑p, p70S6K iso2 (rat): S30‑p, p70S6K (fruit fly):
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE NEK6 (human)

S403-p - p70S6K (human)
Orthologous residues
p70S6K (human): S403‑p, p70S6K iso2 (human): S380‑p, p70S6K (mouse): S403‑p, p70S6K (rat): S403‑p, p70S6K iso2 (rat): S380‑p, p70S6K (fruit fly): S389‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE NEK6 (human)

T412-p - p70S6K (human)
Orthologous residues
p70S6K (human): T412‑p, p70S6K iso2 (human): T389‑p, p70S6K (mouse): T412‑p, p70S6K (rat): T412‑p, p70S6K iso2 (rat): T389‑p, p70S6K (fruit fly): T398‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE NEK6 (human)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
IGF-1 increase
rapamycin IGF-1 inhibit treatment-induced increase

S659-p - Rb-like 2 (human)
Orthologous residues
Rb‑like 2 (human): S659‑p, Rb‑like 2 (mouse): S656‑p, Rb‑like 2 (rat): S656‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE NEK6 (human)

S377-p - SGK1 (human)
Orthologous residues
SGK1 (human): S377‑p, SGK1 iso3 (human): S391‑p, SGK1 (mouse): S377‑p, SGK1 (rat): S376‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE NEK6 (human)

S422-p - SGK1 (human)
Orthologous residues
SGK1 (human): S422‑p, SGK1 iso3 (human): S436‑p, SGK1 (mouse): S422‑p, SGK1 (rat): S421‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE NEK6 (human)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
IGF-1 increase
wortmannin IGF-1 inhibit treatment-induced increase


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