Curated Information
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Curated Information Page
PubMed Id: 11953308 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Kagan A, Melman YF, Krumerman A, McDonald TV (2002) 14-3-3 amplifies and prolongs adrenergic stimulation of HERG K+ channel activity. EMBO J 21, 1889-98 11953308
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S283-p - Kv11.1 (human) ▲
Orthologous residues
Kv11.1 (human): S283‑p, Kv11.1 iso2 (human): ‑, Kv11.1 iso5 (human): S283‑p, Kv11.1 (mouse): S285‑p, Kv11.1 (rat): S285‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  CHO (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  hamster
Downstream Regulation
 Effect of modification (function):  activation, molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
14-3-3 eta (human) Induces yeast two-hybrid, co-immunoprecipitation, in vitro
 Comments:  14-3-3 binding stabilizes phosphorylation of KV11.1, prolonging its activation

S890-p - Kv11.1 (human) ▲
Orthologous residues
Kv11.1 (human): S890‑p, Kv11.1 iso2 (human): S550‑p, Kv11.1 iso5 (human): S890‑p, Kv11.1 (mouse): S892‑p, Kv11.1 (rat): S892‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  CHO (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  hamster

T895-p - Kv11.1 (human) ▲
Orthologous residues
Kv11.1 (human): T895‑p, Kv11.1 iso2 (human): T555‑p, Kv11.1 iso5 (human): T895‑p, Kv11.1 (mouse): T897‑p, Kv11.1 (rat): T897‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  CHO (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  hamster

S1137-p - Kv11.1 (human) ▲
Orthologous residues
Kv11.1 (human): S1137‑p, Kv11.1 iso2 (human): S797‑p, Kv11.1 iso5 (human): S1137‑p, Kv11.1 (mouse): S1140‑p, Kv11.1 (rat): S1141‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  CHO (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  hamster
Downstream Regulation
 Effect of modification (function):  activation, molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
14-3-3 eta (human) Induces yeast two-hybrid, co-immunoprecipitation, in vitro
 Comments:  14-3-3 binding stabilizes phosphorylation of KV11.1, prolonging its activation


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