Curated Information
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Curated Information Page
PubMed Id: 8650547 
Wang XZ, Ron D (1996) Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP Kinase. Science 272, 1347-9 8650547
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S79-p - CHOP (human)
Orthologous residues
CHOP (human): S79‑p, CHOP (mouse): S78‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, immunoprecipitation, mutation of modification site
 Relevant cell lines - cell types - tissues:  3T3 (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  mouse
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE P38A (human)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
MMS increase
SB203580 MMS inhibit treatment-induced increase
tunicamycin increase
glucose increase
Downstream Regulation
 Effect of modification (process):  transcription, altered
 Comments:  CHOP-Gal-4 chimeric protein induced a reporter gene expression.

S82-p - CHOP (human)
Orthologous residues
CHOP (human): S82‑p, CHOP (mouse): S81‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, immunoprecipitation, mutation of modification site
 Relevant cell lines - cell types - tissues:  3T3 (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  mouse
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE P38A (human)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
MMS increase
SB203580 MMS inhibit treatment-induced increase
tunicamycin increase
glucose increase
Downstream Regulation
 Effect of modification (process):  transcription, altered
 Comments:  CHOP-Gal-4 chimeric protein induced a reporter gene expression.


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