Curated Information
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Curated Information Page
PubMed Id: 9832145 
Hanger DP, et al. (1998) New phosphorylation sites identified in hyperphosphorylated tau (paired helical filament-tau) from Alzheimer's disease brain using nanoelectrospray mass spectrometry. J Neurochem 71, 2465-76 9832145
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
Download Sites

T175-p - Tau iso8 (human)
Orthologous residues
Tau (human): T492‑p, Tau iso2 (human): T117‑p, Tau iso3 (human): T81‑p, Tau iso5 (human): T175‑p, Tau iso6 (human): T117‑p, Tau iso7 (human): T146‑p, Tau iso8 (human): T175‑p, Tau (mouse): T467‑p, Tau iso3 (mouse): T164‑p, Tau iso7 (mouse): T106‑p, Tau (rat): T486‑p, Tau (cow): T166‑p
Characterization
 Methods used to characterize site in vivo 2D analysis, mass spectrometry, western blotting
 Disease tissue studied:  Alzheimer's disease
 Relevant cell lines - cell types - tissues:  brain
 Cellular systems studied:  tissue
 Species studied:  human
Associated Diseases
Diseases: Alterations: Comments:
Alzheimer's disease increased

T181-p - Tau iso8 (human)
Orthologous residues
Tau (human): T498‑p, Tau iso2 (human): T123‑p, Tau iso3 (human): T87‑p, Tau iso5 (human): T181‑p, Tau iso6 (human): T123‑p, Tau iso7 (human): T152‑p, Tau iso8 (human): T181‑p, Tau (mouse): T473‑p, Tau iso3 (mouse): T170‑p, Tau iso7 (mouse): T112‑p, Tau (rat): T492‑p, Tau (cow): T172‑p
Characterization
 Methods used to characterize site in vivo 2D analysis, mass spectrometry, western blotting
 Disease tissue studied:  Alzheimer's disease
 Relevant cell lines - cell types - tissues:  brain
 Cellular systems studied:  tissue
 Species studied:  human
Associated Diseases
Diseases: Alterations: Comments:
Alzheimer's disease increased

S184-p - Tau iso8 (human)
Orthologous residues
Tau (human): S501‑p, Tau iso2 (human): S126‑p, Tau iso3 (human): S90‑p, Tau iso5 (human): S184‑p, Tau iso6 (human): S126‑p, Tau iso7 (human): S155‑p, Tau iso8 (human): S184‑p, Tau (mouse): G476‑p, Tau iso3 (mouse): G173‑p, Tau iso7 (mouse): G115‑p, Tau (rat): G495‑p, Tau (cow): S173‑p
Characterization
 Methods used to characterize site in vivo 2D analysis, mass spectrometry, western blotting
 Disease tissue studied:  Alzheimer's disease
 Relevant cell lines - cell types - tissues:  brain
 Cellular systems studied:  tissue
 Species studied:  human
Associated Diseases
Diseases: Alterations: Comments:
Alzheimer's disease increased

S185-p - Tau iso8 (human)
Orthologous residues
Tau (human): S502‑p, Tau iso2 (human): S127‑p, Tau iso3 (human): S91‑p, Tau iso5 (human): S185‑p, Tau iso6 (human): S127‑p, Tau iso7 (human): S156‑p, Tau iso8 (human): S185‑p, Tau (mouse): S477‑p, Tau iso3 (mouse): S174‑p, Tau iso7 (mouse): S132‑p, Tau (rat): S496‑p, Tau (cow): S190‑p
Characterization
 Methods used to characterize site in vivo 2D analysis, mass spectrometry, western blotting
 Disease tissue studied:  Alzheimer's disease
 Relevant cell lines - cell types - tissues:  brain
 Cellular systems studied:  tissue
 Species studied:  human
Associated Diseases
Diseases: Alterations: Comments:
Alzheimer's disease increased

Y197-p - Tau iso8 (human)
Orthologous residues
Tau (human): Y514‑p, Tau iso2 (human): Y139‑p, Tau iso3 (human): Y103‑p, Tau iso5 (human): Y197‑p, Tau iso6 (human): Y139‑p, Tau iso7 (human): Y168‑p, Tau iso8 (human): Y197‑p, Tau (mouse): Y489‑p, Tau iso3 (mouse): Y186‑p, Tau iso7 (mouse): Y146‑p, Tau (rat): Y508‑p, Tau (cow): Y204‑p
Characterization
 Methods used to characterize site in vivo 2D analysis, mass spectrometry, western blotting
 Disease tissue studied:  Alzheimer's disease
 Relevant cell lines - cell types - tissues:  brain
 Cellular systems studied:  tissue
 Species studied:  human
Associated Diseases
Diseases: Alterations: Comments:
Alzheimer's disease increased

S198-p - Tau iso8 (human)
Orthologous residues
Tau (human): S515‑p, Tau iso2 (human): S140‑p, Tau iso3 (human): S104‑p, Tau iso5 (human): S198‑p, Tau iso6 (human): S140‑p, Tau iso7 (human): S169‑p, Tau iso8 (human): S198‑p, Tau (mouse): S490‑p, Tau iso3 (mouse): S187‑p, Tau iso7 (mouse): S147‑p, Tau (rat): S509‑p, Tau (cow): S205‑p
Characterization
 Methods used to characterize site in vivo 2D analysis, mass spectrometry, western blotting
 Disease tissue studied:  Alzheimer's disease
 Relevant cell lines - cell types - tissues:  brain
 Cellular systems studied:  tissue
 Species studied:  human
Associated Diseases
Diseases: Alterations: Comments:
Alzheimer's disease increased

S199-p - Tau iso8 (human)
Orthologous residues
Tau (human): S516‑p, Tau iso2 (human): S141‑p, Tau iso3 (human): S105‑p, Tau iso5 (human): S199‑p, Tau iso6 (human): S141‑p, Tau iso7 (human): S170‑p, Tau iso8 (human): S199‑p, Tau (mouse): S491‑p, Tau iso3 (mouse): S188‑p, Tau iso7 (mouse): S148‑p, Tau (rat): S510‑p, Tau (cow): S206‑p
Characterization
 Methods used to characterize site in vivo 2D analysis, mass spectrometry, western blotting
 Disease tissue studied:  Alzheimer's disease
 Relevant cell lines - cell types - tissues:  brain
 Cellular systems studied:  tissue
 Species studied:  human
Associated Diseases
Diseases: Alterations: Comments:
Alzheimer's disease increased

S202-p - Tau iso8 (human)
Orthologous residues
Tau (human): S519‑p, Tau iso2 (human): S144‑p, Tau iso3 (human): S108‑p, Tau iso5 (human): S202‑p, Tau iso6 (human): S144‑p, Tau iso7 (human): S173‑p, Tau iso8 (human): S202‑p, Tau (mouse): S494‑p, Tau iso3 (mouse): S191‑p, Tau iso7 (mouse): S151‑p, Tau (rat): S513‑p, Tau (cow): S209‑p
Characterization
 Methods used to characterize site in vivo 2D analysis, mass spectrometry, western blotting
 Disease tissue studied:  Alzheimer's disease
 Relevant cell lines - cell types - tissues:  brain
 Cellular systems studied:  tissue
 Species studied:  human
Associated Diseases
Diseases: Alterations: Comments:
Alzheimer's disease increased

S210-p - Tau iso8 (human)
Orthologous residues
Tau (human): S527‑p, Tau iso2 (human): S152‑p, Tau iso3 (human): S116‑p, Tau iso5 (human): S210‑p, Tau iso6 (human): S152‑p, Tau iso7 (human): S181‑p, Tau iso8 (human): S210‑p, Tau (mouse): S502‑p, Tau iso3 (mouse): S199‑p, Tau iso7 (mouse): S159‑p, Tau (rat): S521‑p, Tau (cow): S217‑p
Characterization
 Methods used to characterize site in vivo 2D analysis, mass spectrometry, western blotting
 Disease tissue studied:  Alzheimer's disease
 Relevant cell lines - cell types - tissues:  brain
 Cellular systems studied:  tissue
 Species studied:  human
Associated Diseases
Diseases: Alterations: Comments:
Alzheimer's disease increased

T212-p - Tau iso8 (human)
Orthologous residues
Tau (human): T529‑p, Tau iso2 (human): T154‑p, Tau iso3 (human): T118‑p, Tau iso5 (human): T212‑p, Tau iso6 (human): T154‑p, Tau iso7 (human): T183‑p, Tau iso8 (human): T212‑p, Tau (mouse): T504‑p, Tau iso3 (mouse): T201‑p, Tau iso7 (mouse): T161‑p, Tau (rat): T523‑p, Tau (cow): T219‑p
Characterization
 Methods used to characterize site in vivo 2D analysis, mass spectrometry, western blotting
 Disease tissue studied:  Alzheimer's disease
 Relevant cell lines - cell types - tissues:  brain
 Cellular systems studied:  tissue
 Species studied:  human
Associated Diseases
Diseases: Alterations: Comments:
Alzheimer's disease increased

S214-p - Tau iso8 (human)
Orthologous residues
Tau (human): S531‑p, Tau iso2 (human): S156‑p, Tau iso3 (human): S120‑p, Tau iso5 (human): S214‑p, Tau iso6 (human): S156‑p, Tau iso7 (human): S185‑p, Tau iso8 (human): S214‑p, Tau (mouse): S506‑p, Tau iso3 (mouse): S203‑p, Tau iso7 (mouse): S163‑p, Tau (rat): S525‑p, Tau (cow): S221‑p
Characterization
 Methods used to characterize site in vivo 2D analysis, mass spectrometry, western blotting
 Disease tissue studied:  Alzheimer's disease
 Relevant cell lines - cell types - tissues:  brain
 Cellular systems studied:  tissue
 Species studied:  human
Associated Diseases
Diseases: Alterations: Comments:
Alzheimer's disease increased

T217-p - Tau iso8 (human)
Orthologous residues
Tau (human): T534‑p, Tau iso2 (human): T159‑p, Tau iso3 (human): T123‑p, Tau iso5 (human): T217‑p, Tau iso6 (human): T159‑p, Tau iso7 (human): T188‑p, Tau iso8 (human): T217‑p, Tau (mouse): T509‑p, Tau iso3 (mouse): T206‑p, Tau iso7 (mouse): T166‑p, Tau (rat): T528‑p, Tau (cow): T224‑p
Characterization
 Methods used to characterize site in vivo 2D analysis, mass spectrometry, western blotting
 Disease tissue studied:  Alzheimer's disease
 Relevant cell lines - cell types - tissues:  brain
 Cellular systems studied:  tissue
 Species studied:  human
Associated Diseases
Diseases: Alterations: Comments:
Alzheimer's disease increased

T231-p - Tau iso8 (human)
Orthologous residues
Tau (human): T548‑p, Tau iso2 (human): T173‑p, Tau iso3 (human): T137‑p, Tau iso5 (human): T231‑p, Tau iso6 (human): T173‑p, Tau iso7 (human): T202‑p, Tau iso8 (human): T231‑p, Tau (mouse): T523‑p, Tau iso3 (mouse): T220‑p, Tau iso7 (mouse): T180‑p, Tau (rat): T542‑p, Tau (cow): T238‑p
Characterization
 Methods used to characterize site in vivo 2D analysis, mass spectrometry, western blotting
 Disease tissue studied:  Alzheimer's disease
 Relevant cell lines - cell types - tissues:  brain
 Cellular systems studied:  tissue
 Species studied:  human
Associated Diseases
Diseases: Alterations: Comments:
Alzheimer's disease increased

S235-p - Tau iso8 (human)
Orthologous residues
Tau (human): S552‑p, Tau iso2 (human): S177‑p, Tau iso3 (human): S141‑p, Tau iso5 (human): S235‑p, Tau iso6 (human): S177‑p, Tau iso7 (human): S206‑p, Tau iso8 (human): S235‑p, Tau (mouse): S527‑p, Tau iso3 (mouse): S224‑p, Tau iso7 (mouse): S184‑p, Tau (rat): S546‑p, Tau (cow): S242‑p
Characterization
 Methods used to characterize site in vivo 2D analysis, mass spectrometry, western blotting
 Disease tissue studied:  Alzheimer's disease
 Relevant cell lines - cell types - tissues:  brain
 Cellular systems studied:  tissue
 Species studied:  human
Associated Diseases
Diseases: Alterations: Comments:
Alzheimer's disease increased

S237-p - Tau iso8 (human)
Orthologous residues
Tau (human): S554‑p, Tau iso2 (human): S179‑p, Tau iso3 (human): S143‑p, Tau iso5 (human): S237‑p, Tau iso6 (human): S179‑p, Tau iso7 (human): S208‑p, Tau iso8 (human): S237‑p, Tau (mouse): S529‑p, Tau iso3 (mouse): S226‑p, Tau iso7 (mouse): S186‑p, Tau (rat): S548‑p, Tau (cow): S244‑p
Characterization
 Methods used to characterize site in vivo 2D analysis, mass spectrometry, western blotting
 Disease tissue studied:  Alzheimer's disease
 Relevant cell lines - cell types - tissues:  brain
 Cellular systems studied:  tissue
 Species studied:  human
Associated Diseases
Diseases: Alterations: Comments:
Alzheimer's disease increased

S238-p - Tau iso8 (human)
Orthologous residues
Tau (human): S555‑p, Tau iso2 (human): S180‑p, Tau iso3 (human): S144‑p, Tau iso5 (human): S238‑p, Tau iso6 (human): S180‑p, Tau iso7 (human): S209‑p, Tau iso8 (human): S238‑p, Tau (mouse): A530‑p, Tau iso3 (mouse): A227‑p, Tau iso7 (mouse): A187‑p, Tau (rat): A549‑p, Tau (cow): A245‑p
Characterization
 Methods used to characterize site in vivo 2D analysis, mass spectrometry, western blotting
 Disease tissue studied:  Alzheimer's disease
 Relevant cell lines - cell types - tissues:  brain
 Cellular systems studied:  tissue
 Species studied:  human
Associated Diseases
Diseases: Alterations: Comments:
Alzheimer's disease increased

S262-p - Tau iso8 (human)
Orthologous residues
Tau (human): S579‑p, Tau iso2 (human): S204‑p, Tau iso3 (human): S168‑p, Tau iso5 (human): S262‑p, Tau iso6 (human): S204‑p, Tau iso7 (human): S233‑p, Tau iso8 (human): S262‑p, Tau (mouse): S554‑p, Tau iso3 (mouse): S251‑p, Tau iso7 (mouse): S211‑p, Tau (rat): S573‑p, Tau (cow): S269‑p
Characterization
 Methods used to characterize site in vivo 2D analysis, mass spectrometry, western blotting
 Disease tissue studied:  Alzheimer's disease
 Relevant cell lines - cell types - tissues:  brain
 Cellular systems studied:  tissue
 Species studied:  human
Associated Diseases
Diseases: Alterations: Comments:
Alzheimer's disease increased

S356-p - Tau iso8 (human)
Orthologous residues
Tau (human): S673‑p, Tau iso2 (human): S267‑p, Tau iso3 (human): S231‑p, Tau iso5 (human): S325‑p, Tau iso6 (human): S298‑p, Tau iso7 (human): S327‑p, Tau iso8 (human): S356‑p, Tau (mouse): S648‑p, Tau iso3 (mouse): S345‑p, Tau iso7 (mouse): S305‑p, Tau (rat): S667‑p, Tau (cow): S363‑p
Characterization
 Methods used to characterize site in vivo 2D analysis, mass spectrometry, western blotting
 Disease tissue studied:  Alzheimer's disease
 Relevant cell lines - cell types - tissues:  brain
 Cellular systems studied:  tissue
 Species studied:  human
Associated Diseases
Diseases: Alterations: Comments:
Alzheimer's disease increased

S396-p - Tau iso8 (human)
Orthologous residues
Tau (human): S713‑p, Tau iso2 (human): S307‑p, Tau iso3 (human): S271‑p, Tau iso5 (human): S365‑p, Tau iso6 (human): S338‑p, Tau iso7 (human): S367‑p, Tau iso8 (human): S396‑p, Tau (mouse): S688‑p, Tau iso3 (mouse): S385‑p, Tau iso7 (mouse): S345‑p, Tau (rat): S707‑p, Tau (cow): S403‑p
Characterization
 Methods used to characterize site in vivo 2D analysis, mass spectrometry, western blotting
 Disease tissue studied:  Alzheimer's disease
 Relevant cell lines - cell types - tissues:  brain
 Cellular systems studied:  tissue
 Species studied:  human
Associated Diseases
Diseases: Alterations: Comments:
Alzheimer's disease increased

S400-p - Tau iso8 (human)
Orthologous residues
Tau (human): S717‑p, Tau iso2 (human): S311‑p, Tau iso3 (human): S275‑p, Tau iso5 (human): S369‑p, Tau iso6 (human): S342‑p, Tau iso7 (human): S371‑p, Tau iso8 (human): S400‑p, Tau (mouse): S692‑p, Tau iso3 (mouse): S389‑p, Tau iso7 (mouse): S349‑p, Tau (rat): S711‑p, Tau (cow): S407‑p
Characterization
 Methods used to characterize site in vivo 2D analysis, mass spectrometry, western blotting
 Disease tissue studied:  Alzheimer's disease
 Relevant cell lines - cell types - tissues:  brain
 Cellular systems studied:  tissue
 Species studied:  human
Associated Diseases
Diseases: Alterations: Comments:
Alzheimer's disease increased

T403-p - Tau iso8 (human)
Orthologous residues
Tau (human): T720‑p, Tau iso2 (human): T314‑p, Tau iso3 (human): T278‑p, Tau iso5 (human): T372‑p, Tau iso6 (human): T345‑p, Tau iso7 (human): T374‑p, Tau iso8 (human): T403‑p, Tau (mouse): T695‑p, Tau iso3 (mouse): T392‑p, Tau iso7 (mouse): T352‑p, Tau (rat): T714‑p, Tau (cow): T410‑p
Characterization
 Methods used to characterize site in vivo 2D analysis, mass spectrometry, western blotting
 Disease tissue studied:  Alzheimer's disease
 Relevant cell lines - cell types - tissues:  brain
 Cellular systems studied:  tissue
 Species studied:  human
Associated Diseases
Diseases: Alterations: Comments:
Alzheimer's disease increased

S404-p - Tau iso8 (human)
Orthologous residues
Tau (human): S721‑p, Tau iso2 (human): S315‑p, Tau iso3 (human): S279‑p, Tau iso5 (human): S373‑p, Tau iso6 (human): S346‑p, Tau iso7 (human): S375‑p, Tau iso8 (human): S404‑p, Tau (mouse): S696‑p, Tau iso3 (mouse): S393‑p, Tau iso7 (mouse): S353‑p, Tau (rat): S715‑p, Tau (cow): S411‑p
Characterization
 Methods used to characterize site in vivo 2D analysis, mass spectrometry, western blotting
 Disease tissue studied:  Alzheimer's disease
 Relevant cell lines - cell types - tissues:  brain
 Cellular systems studied:  tissue
 Species studied:  human
Associated Diseases
Diseases: Alterations: Comments:
Alzheimer's disease increased

S409-p - Tau iso8 (human)
Orthologous residues
Tau (human): S726‑p, Tau iso2 (human): S320‑p, Tau iso3 (human): S284‑p, Tau iso5 (human): S378‑p, Tau iso6 (human): S351‑p, Tau iso7 (human): S380‑p, Tau iso8 (human): S409‑p, Tau (mouse): S701‑p, Tau iso3 (mouse): S398‑p, Tau iso7 (mouse): S358‑p, Tau (rat): S720‑p, Tau (cow): S416‑p
Characterization
 Methods used to characterize site in vivo 2D analysis, mass spectrometry, western blotting
 Disease tissue studied:  Alzheimer's disease
 Relevant cell lines - cell types - tissues:  brain
 Cellular systems studied:  tissue
 Species studied:  human
Associated Diseases
Diseases: Alterations: Comments:
Alzheimer's disease increased

S412-p - Tau iso8 (human)
Orthologous residues
Tau (human): S729‑p, Tau iso2 (human): S323‑p, Tau iso3 (human): S287‑p, Tau iso5 (human): S381‑p, Tau iso6 (human): S354‑p, Tau iso7 (human): S383‑p, Tau iso8 (human): S412‑p, Tau (mouse): S704‑p, Tau iso3 (mouse): S401‑p, Tau iso7 (mouse): S361‑p, Tau (rat): S723‑p, Tau (cow): S419‑p
Characterization
 Methods used to characterize site in vivo 2D analysis, mass spectrometry, western blotting
 Disease tissue studied:  Alzheimer's disease
 Relevant cell lines - cell types - tissues:  brain
 Cellular systems studied:  tissue
 Species studied:  human
Associated Diseases
Diseases: Alterations: Comments:
Alzheimer's disease increased

S413-p - Tau iso8 (human)
Orthologous residues
Tau (human): S730‑p, Tau iso2 (human): S324‑p, Tau iso3 (human): S288‑p, Tau iso5 (human): S382‑p, Tau iso6 (human): S355‑p, Tau iso7 (human): S384‑p, Tau iso8 (human): S413‑p, Tau (mouse): S705‑p, Tau iso3 (mouse): S402‑p, Tau iso7 (mouse): S362‑p, Tau (rat): S724‑p, Tau (cow): S420‑p
Characterization
 Methods used to characterize site in vivo 2D analysis, mass spectrometry, western blotting
 Disease tissue studied:  Alzheimer's disease
 Relevant cell lines - cell types - tissues:  brain
 Cellular systems studied:  tissue
 Species studied:  human
Associated Diseases
Diseases: Alterations: Comments:
Alzheimer's disease increased

T414-p - Tau iso8 (human)
Orthologous residues
Tau (human): T731‑p, Tau iso2 (human): T325‑p, Tau iso3 (human): T289‑p, Tau iso5 (human): T383‑p, Tau iso6 (human): T356‑p, Tau iso7 (human): T385‑p, Tau iso8 (human): T414‑p, Tau (mouse): T706‑p, Tau iso3 (mouse): T403‑p, Tau iso7 (mouse): T363‑p, Tau (rat): T725‑p, Tau (cow): T421‑p
Characterization
 Methods used to characterize site in vivo 2D analysis, mass spectrometry, western blotting
 Disease tissue studied:  Alzheimer's disease
 Relevant cell lines - cell types - tissues:  brain
 Cellular systems studied:  tissue
 Species studied:  human
Associated Diseases
Diseases: Alterations: Comments:
Alzheimer's disease increased

S416-p - Tau iso8 (human)
Orthologous residues
Tau (human): S733‑p, Tau iso2 (human): S327‑p, Tau iso3 (human): S291‑p, Tau iso5 (human): S385‑p, Tau iso6 (human): S358‑p, Tau iso7 (human): S387‑p, Tau iso8 (human): S416‑p, Tau (mouse): S708‑p, Tau iso3 (mouse): S405‑p, Tau iso7 (mouse): S365‑p, Tau (rat): S727‑p, Tau (cow): S423‑p
Characterization
 Methods used to characterize site in vivo 2D analysis, mass spectrometry, western blotting
 Disease tissue studied:  Alzheimer's disease
 Relevant cell lines - cell types - tissues:  brain
 Cellular systems studied:  tissue
 Species studied:  human
Associated Diseases
Diseases: Alterations: Comments:
Alzheimer's disease increased


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