Curated Information
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Curated Information Page
PubMed Id: 10195104 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
McDonald BJ, et al. (1998) Adjacent phosphorylation sites on GABAA receptor beta subunits determine regulation by cAMP-dependent protein kinase. Nat Neurosci 1, 23-8 10195104
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S409-p - GABRB1 (mouse)
Orthologous residues
GABRB1 (human): S409‑p, GABRB1 (mouse): S409‑p, GABRB1 (rat): S409‑p, GABRB1 (cow): S409‑p
Characterization
 Methods used to characterize site in vivo 2D analysis, mutation of modification site, phosphopeptide mapping, western blotting
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKACA (human) pharmacological activator of upstream enzyme, mutation in upstream enzyme recognition motif, phosphopeptide analysis
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
forskolin increase
cAMP analog increase
Downstream Regulation
 Effect of modification (function):  activity, induced

S410-p - GABRB1 (mouse)
Orthologous residues
GABRB1 (human): S410‑p, GABRB1 (mouse): S410‑p, GABRB1 (rat): S410‑p, GABRB1 (cow): S410‑p
Characterization
 Methods used to characterize site in vivo 2D analysis, mutation of modification site, phosphopeptide mapping, western blotting
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKACA (human) pharmacological activator of upstream enzyme, mutation in upstream enzyme recognition motif, phosphopeptide analysis
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
forskolin increase
cAMP analog increase
Downstream Regulation
 Effect of modification (function):  activity, induced


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