Curated Information

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Curated Information Page

PubMed Id: 12682012

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Information from this record has been curated, but not yet edited in PhosphoSitePlus^® and may be incomplete.

Higuchi H, Yamashita T, Yoshikawa H, Tohyama M (2003) PKA phosphorylates the p75 receptor and regulates its localization to lipid rafts. EMBO J 22, 1790-800 12682012

S303-p - NGFR (human)

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Orthologous residues

NGFR (human): S303‑p, NGFR (mouse): S296‑p, NGFR (rat): S304‑p, NGFR (chicken): S292‑p

Characterization

Enzymes shown to modify site in vitro:

Type	Enzyme
KINASE	PKACB (human)

Upstream Regulation

Potential in vivo enzymes for site:

Type	Enzyme	Evidence	Notes
KINASE	PKACB (human)	activation of upstream enzyme, pharmacological inhibitor of upstream enzyme, mutation in upstream enzyme recognition motif

Downstream Regulation

Effect of modification (function): intracellular localization

Effect of modification (process): cell growth, altered, cytoskeletal reorganization

Comments: translocation to lipid rafts; inactivation of Rho

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