Curated Information
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Curated Information Page
PubMed Id: 8756628 
Demoulin JB, et al. (1996) A single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9. Mol Cell Biol 16, 4710-6 8756628
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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Y407-p - IL9R (human)
Orthologous residues
IL9R (human): Y407‑p, IL9R (mouse): Y405‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  lymphoma, T cell lymphoma
 Relevant cell lines - cell types - tissues:  BaF3 ('B lymphocyte, precursor'), BW5147 (T lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
IL-9 increase
Downstream Regulation
 Effect of modification (process):  apoptosis, inhibited, cell growth, altered
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
DNA Induces molecular association, regulation EMSA
 Comments:  required for IL9-induced binding to GRR oligonucleotide complex containing activated STAT1-alpha, STAT3 and STAT5.


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