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Orthologous residues
|
|
Casp9 (human): S196‑p, Casp9 (mouse): W234‑p, Casp9 (rat): W234‑p
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|
Characterization
|
|
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling, mass spectrometry, mutation of modification site
|
|
Relevant cell lines - cell types - tissues:
267 (epithelial), 293T (epithelial)
|
|
Cellular systems studied:
cell lines
|
|
Species studied:
human, mouse
|
|
Enzymes shown to modify site in vitro:
|
|
|
|
Upstream Regulation
|
|
Potential in vivo enzymes for site:
|
|
Type
|
Enzyme
|
Evidence
|
Notes
|
|
KINASE
|
Akt1 (human)
|
transfection of constitutively active enzyme, transfection of inactive enzyme
|
Ras(V12) induced phosphorylation of Casp-9.
|
|
|
Downstream Regulation
|
|
Effect of modification (function):
inhibition
|
|
Effect of modification (process):
apoptosis, induced
|
