Daniel JA, et al. (2008) Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo. J Cell Biol 183, 777-83 19047460

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

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S367-p - ATM (mouse) ▲

Modsite: DTRSVEIsQSYVTQR SwissProt Entrez-Gene Orthologous residues ATM (human): S367‑p, ATM (mouse): S367‑p, ATM (rat): S367‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  B lymphocyte-spleen Cellular systems studied:  primary cultured cells Species studied:  mouse Comments:  in triple S367/1899/1987A mutant ATM mice Downstream Regulation Effect of modification (process):  chromatin organization, altered

S1899-p - ATM (mouse) ▲

Modsite: PANSDsEsENFLRCC SwissProt Entrez-Gene Orthologous residues ATM (human): S1893‑p, ATM (mouse): S1899‑p, ATM (rat): S1900‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  B lymphocyte-spleen Cellular systems studied:  primary cultured cells Species studied:  mouse Comments:  in triple S367/1899/1987A mutant ATM mice Downstream Regulation Effect of modification (process):  chromatin organization, altered

S1987-p - ATM (mouse) ▲

Modsite: SPTFEEGsQGTTIsS SwissProt Entrez-Gene Orthologous residues ATM (human): S1981‑p, ATM (mouse): S1987‑p, ATM (rat): S1988‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody Relevant cell lines - cell types - tissues:  B lymphocyte-spleen Cellular systems studied:  primary cultured cells Species studied:  mouse Comments:  in triple S367/1899/1987A mutant ATM mice Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE ATM (mouse) genetic knockout/knockin of upstream enzyme, pharmacological activator of upstream enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes ionizing_radiation increase Downstream Regulation Effect of modification (process):  chromatin organization, altered

S18-p - p53 (mouse) ▲

Modsite: IsLELPLsQEtFsGL SwissProt Entrez-Gene Orthologous residues p53 (human): S15‑p, p53 iso2 (human): S15‑p, p53 iso4 (human): ‑, p53 (mouse): S18‑p, p53 iso2 (mouse): S18‑p, p53 (rat): S15‑p, p53 (rabbit): S15‑p, p53 (green monkey): S15‑p Characterization Methods used to characterize site in vivo:  phospho-antibody Relevant cell lines - cell types - tissues:  B lymphocyte-spleen Cellular systems studied:  primary cultured cells Species studied:  mouse Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE ATM (mouse) genetic knockout/knockin of upstream enzyme, pharmacological activator of upstream enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes ionizing_radiation increase

S957-p - Smc1 (mouse) ▲

Modsite: ISQEEGSsQGEESVS SwissProt Entrez-Gene Orthologous residues Smc1 (human): S957‑p, Smc1 (mouse): S957‑p, Smc1 (rat): S957‑p Characterization Methods used to characterize site in vivo:  phospho-antibody Relevant cell lines - cell types - tissues:  B lymphocyte-spleen Cellular systems studied:  primary cultured cells Species studied:  mouse Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE ATM (mouse) genetic knockout/knockin of upstream enzyme, pharmacological activator of upstream enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes ionizing_radiation increase

S824-p - TIF1B (mouse) ▲

Modsite: LPSAGLssQELSGPG SwissProt Entrez-Gene Orthologous residues TIF1B (human): S824‑p, TIF1B iso2 (human): S742‑p, TIF1B (mouse): S824‑p, TIF1B (rat): S825‑p Characterization Methods used to characterize site in vivo:  phospho-antibody Relevant cell lines - cell types - tissues:  B lymphocyte-spleen Cellular systems studied:  primary cultured cells Species studied:  mouse Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE ATM (mouse) genetic knockout/knockin of upstream enzyme, pharmacological activator of upstream enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes ionizing_radiation increase