Choudhary S, Lu M, Cui R, Brasier AR (2007) Involvement of a novel Rac/RhoA guanosine triphosphatase-nuclear factor-kappaB inducing kinase signaling pathway mediating angiotensin II-induced RelA transactivation. Mol Endocrinol 21, 2203-17 17595324

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

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S176-p - IKKA (human) ▲

Modsite: AKDVDQGsLCtsFVG SwissProt Entrez-Gene Orthologous residues IKKA (human): S176‑p, IKKA (mouse): S176‑p, IKKA (rat): S176‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting Disease tissue studied:  liver cancer Relevant cell lines - cell types - tissues:  HepG2 (hepatic), liver Cellular systems studied:  cell lines, tissue Species studied:  human, rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes angiotensin_2 increase

S177-p - IKKB (human) ▲

Modsite: AkELDQGsLCtsFVG SwissProt Entrez-Gene Orthologous residues IKKB (human): S177‑p, IKKB (mouse): S177‑p, IKKB (rat): S177‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting Disease tissue studied:  liver cancer Relevant cell lines - cell types - tissues:  HepG2 (hepatic), liver Cellular systems studied:  cell lines, tissue Species studied:  human, rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes angiotensin_2 increase

S536-p - NFkB-p65 (human) ▲

Modsite: sGDEDFSsIADMDFS SwissProt Entrez-Gene Orthologous residues NFkB‑p65 (human): S536‑p, NFkB‑p65 (mouse): S534‑p, NFkB‑p65 (rat): S535‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting Disease tissue studied:  liver cancer Relevant cell lines - cell types - tissues:  HepG2 (hepatic), liver Cellular systems studied:  cell lines, tissue Species studied:  human, rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes angiotensin_2 Nik (human) increase botulinum_C3_toxin angiotensin_2 Nik (human) inhibit treatment-induced increase Downstream Regulation Effect of modification (process):  transcription, induced

S535-p - NFkB-p65 (rat) ▲

Modsite: sGDEDFSsIADMDFS SwissProt Entrez-Gene Orthologous residues NFkB‑p65 (human): S536‑p, NFkB‑p65 (mouse): S534‑p, NFkB‑p65 (rat): S535‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting Disease tissue studied:  liver cancer Relevant cell lines - cell types - tissues:  HepG2 (hepatic), liver Cellular systems studied:  cell lines, tissue Species studied:  human, rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes angiotensin_2 increase