Frederick MJ, et al. (2011) Phosphoproteomic analysis of signaling pathways in head and neck squamous cell carcinoma patient samples. Am J Pathol 178, 548-71 21281788

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

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S65-p - 4E-BP1 (human) ▲
Modsite: FLMECrNsPVtktPP SwissProt Entrez-Gene Orthologous residues 4E‑BP1 (human): S65‑p, 4E‑BP1 (mouse): S64‑p, 4E‑BP1 (rat): S64‑p, 4E‑BP1 (fruit fly): S65‑p, 4E‑BP1 (cow): S65‑p Characterization Methods used to characterize site in vivo:  immunoassay, phospho-antibody Associated Diseases Diseases Alterations Comments HNSCC increased

T308-p - Akt1 (human) ▲
Modsite: kDGAtMKtFCGtPEy SwissProt Entrez-Gene Orthologous residues Akt1 (human): T308‑p, Akt1 iso2 (human): T246‑p, Akt1 (mouse): T308‑p, Akt1 (rat): T308‑p, Akt1 (fruit fly): T423‑p, Akt1 (cow): T308‑p Characterization Methods used to characterize site in vivo:  immunoassay, phospho-antibody Associated Diseases Diseases Alterations Comments HNSCC decreased

S473-p - Akt1 (human) ▲
Modsite: RPHFPQFsysAsGtA SwissProt Entrez-Gene Orthologous residues Akt1 (human): S473‑p, Akt1 iso2 (human): S411‑p, Akt1 (mouse): S473‑p, Akt1 (rat): S473‑p, Akt1 (fruit fly): S586‑p, Akt1 (cow): S473‑p Characterization Methods used to characterize site in vivo:  immunoassay, phospho-antibody Associated Diseases Diseases Alterations Comments HNSCC decreased

S99-p - BAD (human) ▲
Modsite: PFrGrsRsAPPNLWA SwissProt Entrez-Gene Orthologous residues BAD (human): S99‑p, BAD (mouse): S136‑p, BAD (rat): S137‑p Characterization Methods used to characterize site in vivo:  immunoassay, phospho-antibody Associated Diseases Diseases Alterations Comments HNSCC increased

S446-p - BRAF (human) ▲
Modsite: KtLGRRDssDDWEIP SwissProt Entrez-Gene Orthologous residues BRAF (human): S446‑p, BRAF (mouse): S431‑p, BRAF iso1 (mouse): S483‑p, BRAF (rat): S483‑p, BRAF (chicken): S486‑p, BRAF (quail): S486‑p Characterization Methods used to characterize site in vivo:  immunoassay, phospho-antibody Associated Diseases Diseases Alterations Comments HNSCC increased

S345-p - Chk1 (human) ▲

Modsite: LVQGIsFsQPtCPDH SwissProt Entrez-Gene Orthologous residues Chk1 (human): S345‑p, Chk1 (mouse): S345‑p, Chk1 (rat): S345‑p, Chk1 (chicken): S345‑p Characterization Methods used to characterize site in vivo:  immunoassay, phospho-antibody, western blotting Disease tissue studied:  cancer, squamous cell carcinoma Relevant cell lines - cell types - tissues:  HN31, HN5 (squamous) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes UV increase Associated Diseases Diseases Alterations Comments HNSCC increased

S33-p - Chk2 (human) ▲

Modsite: tQsQGSSsQsQGIss SwissProt Entrez-Gene Orthologous residues Chk2 (human): S33‑p, Chk2 iso9 (human): S33‑p, Chk2 iso11 (human): S33‑p, Chk2 iso12 (human): S33‑p, Chk2 (mouse): S36‑p, Chk2 (rat): S35‑p Characterization Methods used to characterize site in vivo:  immunoassay, phospho-antibody, western blotting Disease tissue studied:  cancer, squamous cell carcinoma Relevant cell lines - cell types - tissues:  HN31, HN5 (squamous) Cellular systems studied:  cell lines Species studied:  human Associated Diseases Diseases Alterations Comments HNSCC increased

S35-p - Chk2 (human) ▲

Modsite: sQGSSsQsQGIssss SwissProt Entrez-Gene Orthologous residues Chk2 (human): S35‑p, Chk2 iso9 (human): S35‑p, Chk2 iso11 (human): S35‑p, Chk2 iso12 (human): S35‑p, Chk2 (mouse): L38‑p, Chk2 (rat): L37‑p Characterization Methods used to characterize site in vivo:  immunoassay, phospho-antibody, western blotting Disease tissue studied:  cancer, squamous cell carcinoma Relevant cell lines - cell types - tissues:  HN31, HN5 (squamous) Cellular systems studied:  cell lines Species studied:  human Associated Diseases Diseases Alterations Comments HNSCC increased

T41-p - CTNNB1 (human) ▲
Modsite: GIHsGATtTAPsLsG SwissProt Entrez-Gene Orthologous residues CTNNB1 (human): T41‑p, CTNNB1 (mouse): T41‑p, CTNNB1 (rat): T41‑p, CTNNB1 (rabbit): T41‑p Characterization Methods used to characterize site in vivo:  immunoassay, phospho-antibody Associated Diseases Diseases Alterations Comments HNSCC decreased

S45-p - CTNNB1 (human) ▲
Modsite: GATtTAPsLsGkGNP SwissProt Entrez-Gene Orthologous residues CTNNB1 (human): S45‑p, CTNNB1 (mouse): S45‑p, CTNNB1 (rat): S45‑p, CTNNB1 (rabbit): S45‑p Characterization Methods used to characterize site in vivo:  immunoassay, phospho-antibody Associated Diseases Diseases Alterations Comments HNSCC decreased

Y1172-p - EGFR (human) ▲
Modsite: IsLDNPDyQQDFFPk SwissProt Entrez-Gene Orthologous residues EGFR (human): Y1172‑p, EGFR iso2 (human): ‑, EGFR iso5 (human): ‑, EGFR (mouse): Y1172‑p, EGFR (rat): Y1171‑p, EGFR (pig): Y1171‑p Characterization Methods used to characterize site in vivo:  immunoassay, phospho-antibody

S209-p - EIF4E (human) ▲
Modsite: DtATksGsttKNRFV SwissProt Entrez-Gene Orthologous residues EIF4E (human): S209‑p, EIF4E iso2 (human): S240‑p, EIF4E (mouse): S209‑p, EIF4E (rat): S209‑p Characterization Methods used to characterize site in vivo:  immunoassay, phospho-antibody Associated Diseases Diseases Alterations Comments HNSCC increased

T202-p - ERK1 (human) ▲
Modsite: HDHtGFLtEyVAtRW SwissProt Entrez-Gene Orthologous residues ERK1 (human): T202‑p, ERK1 iso2 (human): T202‑p, ERK1 iso3 (human): T202‑p, ERK1 (mouse): T203‑p, ERK1 (rat): T203‑p, ERK1 (hamster): T192‑p Characterization Methods used to characterize site in vivo:  immunoassay, phospho-antibody Associated Diseases Diseases Alterations Comments HNSCC decreased

Y204-p - ERK1 (human) ▲
Modsite: HtGFLtEyVAtRWyr SwissProt Entrez-Gene Orthologous residues ERK1 (human): Y204‑p, ERK1 iso2 (human): Y204‑p, ERK1 iso3 (human): Y204‑p, ERK1 (mouse): Y205‑p, ERK1 (rat): Y205‑p, ERK1 (hamster): Y194‑p Characterization Methods used to characterize site in vivo:  immunoassay, phospho-antibody Associated Diseases Diseases Alterations Comments HNSCC decreased

T24-p - FOXO1A (human) ▲
Modsite: LPRPRSCtWPLPRPE SwissProt Entrez-Gene Orthologous residues FOXO1A (human): T24‑p, FOXO1A (mouse): T24‑p, FOXO1A (rat): T24‑p Characterization Methods used to characterize site in vivo:  immunoassay, phospho-antibody Associated Diseases Diseases Alterations Comments HNSCC decreased

T32-p - FOXO3A (human) ▲
Modsite: QsRPRsCtWPLQRPE SwissProt Entrez-Gene Orthologous residues FOXO3A (human): T32‑p, FOXO3A (mouse): T32‑p, FOXO3A (rat): T32‑p Characterization Methods used to characterize site in vivo:  immunoassay, phospho-antibody Associated Diseases Diseases Alterations Comments HNSCC decreased

Y627-p - GAB1 (human) ▲
Modsite: KGDKQVEyLDLDLDs SwissProt Entrez-Gene Orthologous residues GAB1 (human): Y627‑p, GAB1 iso2 (human): Y657‑p, GAB1 (mouse): Y628‑p, GAB1 (rat): Y626‑p Characterization Methods used to characterize site in vivo:  immunoassay, phospho-antibody Associated Diseases Diseases Alterations Comments HNSCC decreased

Y1248-p - HER2 (human) ▲
Modsite: PtAENPEyLGLDVPV SwissProt Entrez-Gene Orthologous residues HER2 (human): Y1248‑p, HER2 iso2 (human): Y638‑p, HER2 iso5 (human): Y1218‑p, HER2 (mouse): Y1249‑p, HER2 (rat): Y1250‑p Characterization Methods used to characterize site in vivo:  immunoassay, phospho-antibody Associated Diseases Diseases Alterations Comments HNSCC decreased

Y1289-p - HER3 (human) ▲
Modsite: CPAsEQGyEEMRAFQ SwissProt Entrez-Gene Orthologous residues HER3 (human): Y1289‑p, HER3 iso2 (human): ‑, HER3 iso4 (human): Y1230‑p, HER3 (mouse): Y1286‑p, HER3 (rat): Y1286‑p Characterization Methods used to characterize site in vivo:  immunoassay, phospho-antibody Associated Diseases Diseases Alterations Comments HNSCC decreased

S32-p - IkB-alpha (human) ▲
Modsite: LLDDRHDsGLDsMkD SwissProt Entrez-Gene Orthologous residues IkB‑alpha (human): S32‑p, IkB‑alpha (mouse): S32‑p, IkB‑alpha (rat): S32‑p Characterization Methods used to characterize site in vivo:  immunoassay, phospho-antibody Associated Diseases Diseases Alterations Comments HNSCC increased

S616-p - IRS1 (human) ▲
Modsite: DDGyMPMsPGVAPVP SwissProt Entrez-Gene Orthologous residues IRS1 (human): S616‑p, IRS1 (mouse): S612‑p, IRS1 (rat): S612‑p Characterization Methods used to characterize site in vivo:  immunoassay, phospho-antibody Associated Diseases Diseases Alterations Comments HNSCC increased

S334-p - LKB1 (human) ▲
Modsite: DTKDRWRsMtVVPYL SwissProt Entrez-Gene Orthologous residues LKB1 (human): S334‑p, LKB1 iso2 (human): S334‑p, LKB1 (mouse): S334‑p, LKB1 (rat): S334‑p, LKB1 (pig): G240‑p Characterization Methods used to characterize site in vivo:  immunoassay, phospho-antibody Associated Diseases Diseases Alterations Comments HNSCC increased

S218-p - MEK1 (human) ▲
Modsite: VsGQLIDsMANsFVG SwissProt Entrez-Gene Orthologous residues MEK1 (human): S218‑p, MEK1 iso2 (human): S192‑p, MEK1 (mouse): S218‑p, MEK1 (rat): S218‑p, MEK1 (rabbit): S218‑p Characterization Methods used to characterize site in vivo:  immunoassay, phospho-antibody Associated Diseases Diseases Alterations Comments HNSCC increased

S222-p - MEK1 (human) ▲
Modsite: LIDsMANsFVGtRSY SwissProt Entrez-Gene Orthologous residues MEK1 (human): S222‑p, MEK1 iso2 (human): S196‑p, MEK1 (mouse): S222‑p, MEK1 (rat): S222‑p, MEK1 (rabbit): S222‑p Characterization Methods used to characterize site in vivo:  immunoassay, phospho-antibody Associated Diseases Diseases Alterations Comments HNSCC increased

S2448-p - mTOR (human) ▲
Modsite: RsRtRtDsysAGQsV SwissProt Entrez-Gene Orthologous residues mTOR (human): S2448‑p, mTOR (mouse): S2448‑p, mTOR (rat): S2448‑p Characterization Methods used to characterize site in vivo:  immunoassay, phospho-antibody Associated Diseases Diseases Alterations Comments HNSCC increased

S394-p - p70S6K (human) ▲
Modsite: TRQtPVDsPDDStLS SwissProt Entrez-Gene Orthologous residues p70S6K (human): S394‑p, p70S6K iso2 (human): S371‑p, p70S6K (mouse): S394‑p, p70S6K (rat): S394‑p, p70S6K iso2 (rat): S371‑p, p70S6K (fruit fly): S380‑p Characterization Methods used to characterize site in vivo:  immunoassay, phospho-antibody Associated Diseases Diseases Alterations Comments HNSCC decreased

T412-p - p70S6K (human) ▲
Modsite: NQVFLGFtyVAPsVL SwissProt Entrez-Gene Orthologous residues p70S6K (human): T412‑p, p70S6K iso2 (human): T389‑p, p70S6K (mouse): T412‑p, p70S6K (rat): T412‑p, p70S6K iso2 (rat): T389‑p, p70S6K (fruit fly): T398‑p Characterization Methods used to characterize site in vivo:  immunoassay, phospho-antibody Associated Diseases Diseases Alterations Comments HNSCC decreased

S380-p - p90RSK (human) ▲
Modsite: HQLFRGFsFVAtGLM SwissProt Entrez-Gene Orthologous residues p90RSK (human): S380‑p, p90RSK iso2 (human): S389‑p, p90RSK (mouse): S369‑p, p90RSK iso3 (mouse): ‑, p90RSK (rat): S380‑p, p90RSK (chicken): S398‑p Characterization Methods used to characterize site in vivo:  immunoassay, phospho-antibody Associated Diseases Diseases Alterations Comments HNSCC increased

T412-p - PKCI (human) ▲

Modsite: RPGDttstFCGtPNy SwissProt Entrez-Gene Orthologous residues PKCI (human): T412‑p, PKCI (mouse): T411‑p, PKCI (rat): T412‑p Characterization Methods used to characterize site in vivo:  immunoassay, phospho-antibody, western blotting Disease tissue studied:  cancer, squamous cell carcinoma Relevant cell lines - cell types - tissues:  FaDu (squamous), HN31, HN5 (squamous), OSC-19 (intestinal), SCC61 (squamous), UMSCC1 (squamous) Cellular systems studied:  cell lines Species studied:  human Downstream Regulation Effect of modification (function):  enzymatic activity, induced Associated Diseases Diseases Alterations Comments HNSCC increased

T410-p - PKCZ (human) ▲

Modsite: GPGDtTstFCGtPNy SwissProt Entrez-Gene Orthologous residues PKCZ (human): T410‑p, PKCZ iso2 (human): T227‑p, PKCZ iso3 (human): T306‑p, PKCZ (mouse): T410‑p, PKCZ (rat): T410‑p Characterization Methods used to characterize site in vivo:  immunoassay, phospho-antibody, western blotting Disease tissue studied:  cancer, squamous cell carcinoma Relevant cell lines - cell types - tissues:  FaDu (squamous), HN31, HN5 (squamous), OSC-19 (intestinal), SCC61 (squamous), UMSCC1 (squamous) Cellular systems studied:  cell lines Species studied:  human Downstream Regulation Effect of modification (function):  enzymatic activity, induced Associated Diseases Diseases Alterations Comments HNSCC increased

Y783-p - PLCG1 (human) ▲
Modsite: EGRNPGFyVEANPMP SwissProt Entrez-Gene Orthologous residues PLCG1 (human): Y783‑p, PLCG1 iso2 (human): Y783‑p, PLCG1 (mouse): Y783‑p, PLCG1 (rat): Y783‑p, PLCG1 (cow): Y783‑p Characterization Methods used to characterize site in vivo:  immunoassay, phospho-antibody Associated Diseases Diseases Alterations Comments HNSCC increased

Y427-p - SHC1 (human) ▲

Modsite: ELFDDPsyVNVQNLD SwissProt Entrez-Gene Orthologous residues SHC1 (human): Y427‑p, SHC1 iso2 (human): Y317‑p, SHC1 iso3 (human): Y272‑p, SHC1 iso6 (human): Y428‑p, SHC1 iso7 (human): Y318‑p, SHC1 (mouse): Y423‑p, SHC1 iso2 (mouse): Y313‑p, SHC1 iso3 (mouse): Y268‑p, SHC1 (rat): Y423‑p, SHC1 iso2 (rat): Y313‑p Characterization Methods used to characterize site in vivo:  immunoassay, phospho-antibody Associated Diseases Diseases Alterations Comments HNSCC decreased

S465-p - SMAD2 (human) ▲
Modsite: sPsVRCssMs_____ SwissProt Entrez-Gene Orthologous residues SMAD2 (human): S465‑p, SMAD2 (mouse): S465‑p, SMAD2 (rat): S465‑p, SMAD2 (cow): S465‑p Characterization Methods used to characterize site in vivo:  immunoassay, phospho-antibody Associated Diseases Diseases Alterations Comments HNSCC increased

S467-p - SMAD2 (human) ▲
Modsite: sVRCssMs_______ SwissProt Entrez-Gene Orthologous residues SMAD2 (human): S467‑p, SMAD2 (mouse): S467‑p, SMAD2 (rat): S467‑p, SMAD2 (cow): S467‑p Characterization Methods used to characterize site in vivo:  immunoassay, phospho-antibody Associated Diseases Diseases Alterations Comments HNSCC increased

Y705-p - STAT3 (human) ▲

Modsite: DPGsAAPyLktKFIC SwissProt Entrez-Gene Orthologous residues STAT3 (human): Y705‑p, STAT3 iso2 (human): Y704‑p, STAT3 iso3 (human): Y705‑p, STAT3 (mouse): Y705‑p, STAT3 iso2 (mouse): Y705‑p, STAT3 iso3 (mouse): Y704‑p, STAT3 (rat): Y705‑p, STAT3 (cow): Y705‑p Characterization Methods used to characterize site in vivo:  immunoassay, phospho-antibody Associated Diseases Diseases Alterations Comments HNSCC increased

S727-p - STAT3 (human) ▲

Modsite: NtIDLPMsPrTLDSL SwissProt Entrez-Gene Orthologous residues STAT3 (human): S727‑p, STAT3 iso2 (human): S726‑p, STAT3 iso3 (human): ‑, STAT3 (mouse): S727‑p, STAT3 iso2 (mouse): ‑, STAT3 iso3 (mouse): S726‑p, STAT3 (rat): S727‑p, STAT3 (cow): S727‑p Characterization Methods used to characterize site in vivo:  immunoassay, phospho-antibody Associated Diseases Diseases Alterations Comments HNSCC increased

Y694-p - STAT5A (human) ▲
Modsite: LAkAVDGyVkPQIkQ SwissProt Entrez-Gene Orthologous residues STAT5A (human): Y694‑p, STAT5A (mouse): Y694‑p, STAT5A iso2 (mouse): ‑, STAT5A (rat): Y694‑p, STAT5A (fruit fly): ‑, STAT5A (sheep): Y694‑p Characterization Methods used to characterize site in vivo:  immunoassay, phospho-antibody Associated Diseases Diseases Alterations Comments HNSCC decreased

Y951-p - VEGFR2 (human) ▲
Modsite: RFRQGKDyVGAIPVD SwissProt Entrez-Gene Orthologous residues VEGFR2 (human): Y951‑p, VEGFR2 (mouse): Y949‑p, VEGFR2 (rat): Y947‑p Characterization Methods used to characterize site in vivo:  immunoassay, phospho-antibody Associated Diseases Diseases Alterations Comments HNSCC decreased

Y996-p - VEGFR2 (human) ▲
Modsite: EEAPEDLyKDFLTLE SwissProt Entrez-Gene Orthologous residues VEGFR2 (human): Y996‑p, VEGFR2 (mouse): Y994‑p, VEGFR2 (rat): Y992‑p Characterization Methods used to characterize site in vivo:  immunoassay, phospho-antibody Associated Diseases Diseases Alterations Comments HNSCC decreased