Curated Information
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PubMed Id: 20484410 
Blancquaert S, et al. (2010) cAMP-dependent activation of mammalian target of rapamycin (mTOR) in thyroid cells. Implication in mitogenesis and activation of CDK4. Mol Endocrinol 24, 1453-68 20484410
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
Click on the protein name to open the protein page, and on the RSD number to open the site page.
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T172-p - CDK4 (human)
Modsite: YSYQMALtPVVVTLW SwissProt Entrez-Gene
Orthologous residues
CDK4 (human): T172‑p, CDK4 (mouse): T172‑p, CDK4 (rat): T172‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
TSH increase
rapamycin TSH inhibit treatment-induced increase
insulin increase
rapamycin insulin inhibit treatment-induced increase

T246-p - PRAS40 (human)
Modsite: LPRPRLNtSDFQKLK SwissProt Entrez-Gene
Orthologous residues
PRAS40 (human): T246‑p, PRAS40 iso3 (human): T266‑p, PRAS40 (mouse): T247‑p, PRAS40 (rat): T247‑p

T252-p - p70S6K (rat)
Modsite: HDGTVTHtFCGTIEY SwissProt Entrez-Gene
Orthologous residues
p70S6K (human): T252‑p, p70S6K iso2 (human): T229‑p, p70S6K (mouse): T252‑p, p70S6K (rat): T252‑p, p70S6K iso2 (rat): T229‑p, p70S6K (fruit fly): T238‑p

T412-p - p70S6K (rat)
Modsite: NQVFLGFtYVAPSVL SwissProt Entrez-Gene
Orthologous residues
p70S6K (human): T412‑p, p70S6K iso2 (human): T389‑p, p70S6K (mouse): T412‑p, p70S6K (rat): T412‑p, p70S6K iso2 (rat): T389‑p, p70S6K (fruit fly): T398‑p

T444-p - p70S6K (rat)
Modsite: RFIGSPRtPVSPVKF SwissProt Entrez-Gene
Orthologous residues
p70S6K (human): T444‑p, p70S6K iso2 (human): T421‑p, p70S6K (mouse): T444‑p, p70S6K (rat): T444‑p, p70S6K iso2 (rat): T421‑p, p70S6K (fruit fly): S429‑p

S447-p - p70S6K (rat)
Modsite: GSPRTPVsPVKFSPG SwissProt Entrez-Gene
Orthologous residues
p70S6K (human): S447‑p, p70S6K iso2 (human): S424‑p, p70S6K (mouse): S447‑p, p70S6K (rat): S447‑p, p70S6K iso2 (rat): S424‑p, p70S6K (fruit fly): S430‑p

T247-p - PRAS40 (rat)
Modsite: LPRPRLNtSDFQKLK SwissProt Entrez-Gene
Orthologous residues
PRAS40 (human): T246‑p, PRAS40 iso3 (human): T266‑p, PRAS40 (mouse): T247‑p, PRAS40 (rat): T247‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase

S772-p - Rb (rat)
Modsite: STRPPTLsPIPHIPR SwissProt Entrez-Gene
Orthologous residues
Rb (human): S780‑p, Rb (mouse): S773‑p, Rb (rat): S772‑p

T818-p - Rb (rat)
Modsite: LPTPTKMtPRSRILV SwissProt Entrez-Gene
Orthologous residues
Rb (human): T826‑p, Rb (mouse): T819‑p, Rb (rat): T818‑p

S235-p - S6 (rat)
Modsite: IAKRRRLsSLRASTS SwissProt Entrez-Gene
Orthologous residues
S6 (human): S235‑p, S6 (mouse): S235‑p, S6 (rat): S235‑p, S6 (fruit fly): A234‑p

S236-p - S6 (rat)
Modsite: AKRRRLSsLRASTSK SwissProt Entrez-Gene
Orthologous residues
S6 (human): S236‑p, S6 (mouse): S236‑p, S6 (rat): S236‑p, S6 (fruit fly): S235‑p

T1466-p - TSC2 (rat)
Modsite: GLRPRGYtISDSAPS SwissProt Entrez-Gene
Orthologous residues
TSC2 (human): T1462‑p, TSC2 iso2 (human): T1419‑p, TSC2 iso3 (human): T1418‑p, TSC2 iso4 (human): T1439‑p, TSC2 (mouse): T1465‑p, TSC2 iso6 (mouse): T1443‑p, TSC2 (rat): T1466‑p, TSC2 iso2 (rat): T1423‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase

Y1573-p - TSC2 (rat)
Modsite: NEHGSYRyTEFLTGL SwissProt Entrez-Gene
Orthologous residues
TSC2 (human): Y1571‑p, TSC2 iso2 (human): Y1528‑p, TSC2 iso3 (human): Y1527‑p, TSC2 iso4 (human): Y1548‑p, TSC2 (mouse): Y1572‑p, TSC2 iso6 (mouse): Y1550‑p, TSC2 (rat): Y1573‑p, TSC2 iso2 (rat): Y1530‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase


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